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Metternich Rainer: Peptide boronic acid derivatives having protease inhibiting activity.. Sandoz, Sandoz, Sandoz, February 19, 1992: EP0471651-A2 (84 worldwide citation)

Borolysine peptidomimetics of formula I wherein W, Y, R4, R5, Q1 and Q2 are defined in claim 1 are potent thrombin inhibitors.


3
Kottirsch Georg, Metternich Rainer: New derivatives of beta-amino acids with anti-thrombotic activity.. Sandoz, Sandoz, Sandoz, September 15, 1993: EP0560730-A2 (12 worldwide citation)

Pseudopeptides of formula I in free or salt form wherein A, B, R1, X, Y and m are defined as in claim 1, and their use in the prophylactic and acute treatment of thrombosis.


4
Hagenbach Alexander, Metternich Rainer, Pfenninger Emil, Weidmann Beat: Resin inhibitators. Sandoz, July 22, 1988: FR2609716-A1

LA PRESENTE INVENTION A POUR OBJET DES COMPOSES DE FORMULE :(CF DESSIN DANS BOPI)DANS LAQUELLE A, B, C, D, Y, R, R, R, R ET R SIGNIFIENT DES RESTES ORGANIQUES VARIES.CES COMPOSES EXERCENT UNE ACTIVITE INHIBITRICE DE LA RENINE ET SONT UTILISES CONTRE L'HYPERTENSION ET L'INSUFFISANCE CARDIAQUE.


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Metternich Rainer, Tapparelli Carlo, Wienand Anette: Inhibitors of serine proteases, bearing a chelating group. Sandoz, Sandoz Patent, Sandoz Erfindungen Verwaltungsgesellschaft Mbh, Metternich Rainer, Tapparelli Carlo, Wienand Anette, SANDOZ, August 3, 1995: WO/1995/020603

A trypsin-like serine protease inhibiting peptide or pseudo-peptide bearing a chelating group capable of complexing a detectable element, the chelating group being linked to an amino group of the peptide or pseudo-peptide such that the chelating group does not interfere with or prevent the binding o ...


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Metternich Rainer, Tapparelli Carlo, Wienand Anette: Inhibitors of serine proteases, bearing a chelating group. Sandoz, Sandoz, Sandoz, November 13, 1996: EP0741747-A1

A trypsin-like serine protease inhibiting peptide or pseudo-peptide bearing a chelating group capable of complexing a detectable element, the chelating group being linked to an amino group of the peptide or pseudo-peptide such that the chelating group does not interfere with or prevent the binding o ...


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Cook Nigel Scott, Metternich Rainer, Tapparelli Carlo, Wienand Anette: Peptide boronic acid derivatives having protease inhibiting activity. Sandoz, Sandoz, Sandoz, December 27, 1995: EP0688336-A1

Peptidomimetics of formula (I), wherein W, Y, R4, R5, Q1 and Q2 are defined in claim 1 are potent thrombin inhibitors.


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Kottirsch Georg, Metternich Rainer: New derivative of beta-amino acid. Sandoz, March 8, 1994: JP1994-065175

PURPOSE: To provide the subject new compound useful as an anti-thrombotic agent, which has anti-thrombin activity and inhibits the binding of fibrinogen to blood platelet. CONSTITUTION: The objective compound of formula I {R1 is COOH, COOLi or a COO(1-4C alkyl); X is CH2, -CH=, CO or the like; Y is ...


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Metternich Rainer: Improvement in organic chemistry. Sandoz, November 18, 1992: JP1992-330094

PURPOSE: To provide a new compd. which has serine protease inhibiting activity, suppresses production of thrombin and is used for the prevention and treatment of thrombotic embolism by the reaction of a peptide having a specified amino acid sequence and a pinane diol containing azide group, etc. CON ...