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Mertelsmann Roland, Welte Karl, Venuta Salvatore: Purification of interleukin 2.. Sloan Kettering Inst Cancer, October 26, 1983: EP0092163-A2 (35 worldwide citation)

Interleukin 2 (IL 2; T-cell growth factor), produced with and without costimulation by Burkitt's lymphoma line Daudi, is purified approximately 37,000-fold to apparent homogeneity from lymphocyte-conditioned medium by (NH4)2SO4- precipitation, ion-exchange chromatography, gel filtration and hydropho ...


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Feickert Hans Joachim, Welte Karl, Mertelsmann Roland: Anti-interleukin-2 monoclonal antibodies.. Sloan Kettering Inst Cancer, June 20, 1984: EP0111344-A2 (18 worldwide citation)

Monoclonal antibodies recognizing interleukin-2 (IL-2) of various species (human, rat, mouse) are disclosed. These antibodies are useful in purification of IL-2 from biological sample as well as in separating IL-2 into various sub-species. Immunoassay of IL-2 and identification of cells containing I ...


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Welte Karl, Platzer Erich, Gabrilove Janice L, Mertelsmann Roland, Moore Malcolm As: Facteur hematopoietique pluripotentiel humain, stimulant les colonies; methode de preparation et utilisation, Human pluripotent hematopoietic colony stimulating factor, method of production and use. Welte Karl, Platzer Erich, Gabrilove Janice L, Mertelsmann Roland, Moore Malcolm, Sloan Kettering Institute For Cancer Research, OGILVY RENAULT SENCRL, December 15, 1998: CA1340266

Highly purified pluripotent hematopoieticcolony-stimulating factor (pluripotent CSF), a glycoprotein (MW19,600) constitutively produced by human tumor cells hasbeen highly purified from low serum-containingconditioned medium to apparent homogeneity. Pluripotent CSF supports the growth of human mixed ...


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Mertelsmann Roland, Kulmburg Peter, Rosenthal Felicia: (De) Zellen mit hybridrezeptor und dadurch steuerbarem genkonstrukt, und verwendung dieser zellen in der gentherapie, (En) Cells with hybrid receptor and gene construct which can be controlled by said hybrid receptor, and use of said cells in gene therapy. Klinikum Der Albert Ludwigs Universität Freiburg, Mertelsmann Roland, Kulmburg Peter, Rosenthal Felicia, LEDERER KELLER Prinzregentenstrasse 16D 80538 München, June 12, 1997: WO/1997/020938

(EN) The present invention relates to cells with a hybrid receptor comprising a receptor part localised on the outside of the cell and specific to a particular signal molecule and a receptor part originating from another receptor, localised on the inside of the cell and capable of setting off a sign ...


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Mertelsmann Roland, Rosenthal Felicia, Kulmburg Peter, Stark Björn G, Tanczos Eszter, Kopp Jürgen: (De) Fibroblasten mit einem fremdgen enthaltende zusammensetzung zur behandlung von wunden, (En) Fibroblasts with a foreign gene-containing composition for treating wounds. Klinikum Der Albert Ludwigs Universität Freiburg, Mertelsmann Roland, Rosenthal Felicia, Kulmburg Peter, Stark Björn G, Tanczos Eszter, Kopp Jürgen, BEST Michael, October 29, 1998: WO/1998/048012

(EN) A composition for treating wounds comprises fibroblasts which contain at least one foreign gene coding for a cytokine that promotes wound healing and at least another component that promotes wound healing.(DE) Die vorliegende Erfindung offenbart eine Zusammensetzung zur Behandlung von Wunden, d ...


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Rosenthal Felicia M, Lindemann Albrecht, Boehm Thomas, Mertelsmann Roland, Veelken Hendrik, Kulmburg Peter: Method for preparing clonogenic fibroblasts, method for gene transfection of fibroblasts and gene-transfected fibroblasts so obtained. Univ Ludwigs Albert, December 18, 1996: EP0748374-A1

In a method for preparing clonogenic fibroblasts, tissue is taken from the donor and the cells isolated from the tissue, the cell suspension so obtained is sieved, the cells contained in the cell suspension are grown and the cells are transferred to a tissue culture; alternatively, the cells are iso ...