1
David H Chantry, Merl F Hoekstra, Douglas A Holtzman: Lipid kinase. ICOS Corporation, Marshall O Toole Gerstein Murray & Borun, January 12, 1999: US05858753 (83 worldwide citation)

The present invention generally relates to a novel catalytic subunit of a lipid kinase designated p110.delta.. Polynucleotides encoding p110.delta. and recombinant p110.delta. polypeptides are provided along with antibodies to p110.delta., assays for identifying inhibitors of p110.delta., and the li ...


2
David H Chantry, Merl F Hoekstra, Douglas A Holtzman: Lipid kinase. ICOS Corporation, Marshall O Toole Gerstein Murray & Borun, November 16, 1999: US05985589 (80 worldwide citation)

The present invention generally relates to a novel catalytic subunit of a lipid kinase designated p110.delta.. Polynucleotides encoding p110.delta. and recombinant p110.delta. polypeptides are provided along with antibodies to p110.delta., assays for identifying inhibitors of p110.delta., and the li ...


3
David H Chantry, Merl F Hoekstra, Douglas A Holtzman: Lipid kinase. ICOS Corporation, Marshall O Toole Gerstein Murray & Borun, March 16, 1999: US05882910 (31 worldwide citation)

The present invention generally relates to a novel catalytic subunit of a lipid kinase designated p110.delta.. Polynucleotides encoding p110.delta. and recombinant p110.delta. polypeptides are provided along with antibodies to p110.delta., assays for identifying inhibitors of p110.delta., and the li ...


4
Igor V Kutyavin, David Milesi, Merl F Hoekstra: Abasic site endonuclease assay. Epoch Biosciences, Townsend and Townsend and Crew, August 7, 2007: US07252940 (25 worldwide citation)

The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.


5
David Chantry, Patrick W Gray, Merl F Hoekstra: G protein-coupled receptor kinase GRK6. ICOS Corporation, Marshall O Toole Gerstein Murray & Borun, July 2, 1996: US05532151 (8 worldwide citation)

The present invention provides purified and isolated polynucleotide sequences encoding the novel G protein-coupled receptor kinase designated GRK6. Also provided by the invention are methods and materials for the recombinant production of GRK6 enzyme and methods for identifying compounds which modul ...


6
Wei Huang, Merl F Hoekstra, J Richard Sportsman, Ewald A Terpetschnig: Molecular modification assays. Molecular Devices Corporation, Kolisch Hartwell P C, July 4, 2006: US07070921 (7 worldwide citation)

Assays for detecting molecular modifications such as phosphate modifications and the presence and/or activity of enzymes and other agents involved in facilitating or otherwise regulating such modifications.


7
David Chantry, Patrick W Gray, Merl F Hoekstra: G protein-coupled receptor kinase GRK6. ICOS Corporation, Marshall O Toole Gerstein Murray & Borun, January 7, 1997: US05591618 (7 worldwide citation)

The present invention provides purified and isolated polynucleotide sequences encoding the novel G protein-coupled receptor kinase designated GRK6. Also provided by the invention are methods and materials for the recombinant production of GRK6 enzyme and methods for identifying compounds which modul ...


8
Merl F Hoekstra: Protein kinases. Salk Institute for Biological Studies, Marshall O Toole Gerstein Murray & Borun, May 26, 1998: US05756289 (5 worldwide citation)

Protein kinase mutant and wild-type genes encoding polypeptides of the class heretofore designated "casein kinase I" and useful in screening compositions which may affect DNA double-strand break repair activity are disclosed. Also disclosed are methods using the polynucleotides in cell-proliferative ...


9
Igor V Kutyavin, David Milesi, Merl F Hoekstra: Abasic site endonuclease assay. Elitech Holding, Jackson Walker L, September 7, 2010: US07790385 (2 worldwide citation)

The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.


10
Merl F Hoekstra, Mathew J Thayer: Materials and methods for modulating differentiation. Oregon Health Science University, Marshall O Toole Gerstein Murray & Borun, June 6, 2000: US06071691 (2 worldwide citation)

This invention generally relates to materials and methods for modulating the differentiation of cells. Specifically provided are methods to promote or inhibit cell differentiation and methods to identify compounds that promote cellular differentiation.