1
Donna R Cody, Sheila H H DeWitt, John C Hodges, John S Kiely, Walter H Moos, Michael R Pavia, Bruce D Roth, Mel C Schroeder, Charles J Stankovic: Apparatus for multiple simultaneous synthesis. Warner Lambert Company, Charles W Almer III, Francis J Tinney, June 28, 1994: US05324483 (194 worldwide citation)

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, hav ...


2
Sheila H H DeWitt, John S Kiely, Michael R Pavia, Mel C Schroeder, Charles J Stankovic: System for multiple simultaneous synthesis. Warner Lambert Company, Charles W Almer, Francis J Tinney, February 3, 1998: US05714127 (44 worldwide citation)

A system for the multiple, simultaneous synthesis of compounds preferably uses a reaction apparatus comprising a reservoir rack having a plurality of reaction wells, a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends, a holder block, having a plurality of ...


3
Sheila H H DeWitt, John S Kiely, Michael R Pavia, Mel C Schroeder, Charles J Stankovic: Apparatus for multiple simultaneous synthesis. Warner Lambert Company, Charles W Almer III, Francis J Tinney, January 14, 1997: US05593642 (33 worldwide citation)

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, hav ...


4
Donna R Cody, Sheila H H DeWitt, John C Hodges, John S Kiely, Walter H Moos, Michael R Pavia, Bruce D Roth, Mel C Schroeder, Charles J Stankovic: Apparatus and method for multiple simultaneous synthesis. Warner Lambert Company, Francis J Tinney, Charles W Almer III, March 18, 1997: US05612002 (24 worldwide citation)

A method for the multiple, simultaneous synthesis of compounds comprising the steps of: 1) providing an apparatus comprising a plurality of reaction tubes having filter members on their lower ends, a reservoir member for receiving the filter member, a holder member having a plurality of apertures fo ...


5
John M Domagala, John S Kiely, Mel C Schroeder: Individual stereosiomers of 7-[3-(aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones as antibacterial agents. Warner Lambert Company, Charles W Ashbrook, October 8, 1996: US05563155 (19 worldwide citation)

Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.


6
John M Domagala, Mel C Schroeder: Process for quinoline-3-carboxylic acid antibacterial agents. Warner Lambert Company, Ronald A Daignault, March 25, 1986: US04578473 (17 worldwide citation)

An improved process for the preparation of 7-substituted amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids is described where an alkyl ester of a 6,7,8-trifluoro precursor is converted to a trialkylsilyl ester which fluorine at C.sub.7 is directly displaced to the desire ...


7
John S Kiely, Lawrence E Lesheski, Mel C Schroeder: Preparation of certain 7-substituted quinolones. Warner Lambert Company, Elizabeth M Anderson, July 31, 1990: US04945160 (15 worldwide citation)

Novel processes for the coupling of alkyl, alkenyl, alkynyl, or aryl groups to the seven position of quinolines and naphthyridines is disclosed. Novel intermediates and final compounds having antibacterial activity are also described as well as the formulations for the same use.


8
Sheila H H DeWitt, John S Kiely, Michael R Pavia, Mel C Schroeder, Charles J Stankovic: Apparatus for multiple simultaneous synthesis. Warner Lambert Company, Charles W Almer III, Francis J Tinney, December 10, 1996: US05582801 (9 worldwide citation)

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, hav ...


9
Sheila H H DeWitt, Michael Kell, Michael R Pavia, John S Kiely, Mel C Schroeder, Charles J Stankovic, Steven Ware: Apparatus and method for multiple simultaneous synthesis. Warner Lambert Company, Charles W Almer, December 30, 1997: US05702672 (9 worldwide citation)

An apparatus for multiple, simultaneous synthesis of compounds which consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may ...


10
Sheila H H DeWitt, John S Kiely, Michael R Pavia, Mel C Schroeder, Charles J Stankovic: Apparatus and method for multiple simultaneous synthesis. Warner Lambert Company, Charles W Almer III, Francis J Tinney, October 15, 1996: US05565173 (7 worldwide citation)

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction cubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, hav ...