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Meguro Kanji, Fujita Takeshi: Thiazolidinedione derivatives, their production and use.. Takeda Chemical Industries, September 3, 1986: EP0193256-A1 (94 worldwide citation)

Thiazolidinedione derivatives of the formula: or pharmacologically acceptable salts thereof are novel compounds, which exhibit in mammals blood sugar- and lipid-lowering activity, and are of value as a therapeutic agent for diabetes and therapeutic agent for hyperlipemia.


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Meguro Kanji, Fujita Takeshi: Thiazolidinedione derivatives, their production and use.. Takeda Chemical Industries, April 9, 1986: EP0177353-A2 (59 worldwide citation)

Thiazolidinedione derivatives of the general formula: [wherein R is hydrogen or a hydrocarbon residue or heterocyclic residue which may each be substituted; R is hydrogen or lower alkyl which may be substituted by hydroxyl group; X is an oxygen or sulfur atom; Z is a hydroxylated methylene or carbon ...


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Meguro Kanji, Fujita Takeshi: Thiazolidinedione derivatives, their production and use.. Takeda Chemical Industries, September 25, 1985: EP0155845-A1 (33 worldwide citation)

Thiazolidinedione derivatives of the general formula: [wherein R and R are the same or different and each represent hydrogen or a lower alkyl group; R is hydrogen or an acyl group; n is 0 or 1] and salts thereof are novel compounds, which exhibit in mammals blood sugar- and lipid-lowering activity, ...


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Meguro Kanji, Ikeda Hitoshi: Quinoline derivatives, their production and use.. Takeda Chemical Industries, February 21, 1990: EP0354994-A2 (26 worldwide citation)

Quinoline derivatives of the formula : ,wherein R is hydrogen, alkyl or aralkyl; m and n are 0 or 1, and each of rings A, B and C can have substituents, which are useful as inhibitors for acyl-CoA : Cholesterol-acyltransferase.


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Meguro Kanji, Fujita Takeshi, Hatanaka Chitoshi, Ooi Satoru: A method for producing thiazolidinedione derivatives.. Takeda Chemical Industries, March 2, 1988: EP0257781-A1 (25 worldwide citation)

A compound of the formula: (wherein R is hydrogen or a lower alkyl) can be produced advantageously by (1) reacting a compound of the formula: (wherein R has the meaning given above) with a halogenating agent or sulfonyl halide to give a compound of the formula: (wherein R has the meaning given above ...


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Tawada Hiroyuki, Meguro Kanji, Ikeda Hitoshi: Benzocycloalkane derivatives and production thereof.. Takeda Chemical Industries, November 28, 1990: EP0399422-A1 (22 worldwide citation)

Benzocycloalkane derivative of the formula wherein R is a hydrogen atom or a hydrocarbon residue, which may optionally have one or more substituents, Ar is an aromatic group, X is an oxygen or sulfur atom, l is 0 or 1, m is 3 to 6 and n is 0 to 2, wherein the ring A and the group Ar each may optiona ...


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Kuwada Yutaka, Meguro Kanji, Miyano Hiroshi: 3-carbamoylamino-4-phenyl quinoline compounds. Takeda Chemical, Wenderoth Lind & Ponack, January 21, 1975: US3862152 (13 worldwide citation)

The present invention relates to novel quinoline derivatives, which have an antiulcer action, and also relates to a method for the production thereof.The present inventors studied quinoline derivatives and succeeded in synthesizing novel quinoline derivatives and further found out that these novel 3 ...


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