1
Wallace Donald G, Piez Karl A, Smestad Thomas L, Seyedin Saeid, Mcpherson John M, Armstrong Rosa: Bone repair using collagen.. Collagen, February 12, 1986: EP0171176-A2 (44 worldwide citation)

A composition for repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or a mixture thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may als ...


2
Sundsmo John S, Ksander George A, Mcpherson John M, Ross Russel, Sprugel Katherine H: Wound healing composition.. Collagen, Univ Washington, October 28, 1987: EP0243179-A1 (44 worldwide citation)

A soft tissue wound healing composition comprising a mixture of fibrillar collagen, heparin, and an effective amount of a growth, chemotactic or differentiation factor, preferably FGF or PDGF in which the factor may be incorporated as synthetic or purified factor or in the form of undegranulated pla ...


3
Mcpherson John M, Twardzik Daniel R, Todaro George J, Piez Karl A, Ranchalis Jane E: Use of cartilage-inducing factor b (cif-b) for the manufacture of a medicament for inhibiting tumor growth.. Collagen, Oncogen, June 15, 1988: EP0271211-A2 (10 worldwide citation)

A polypeptide called cartilage-inducing factor B (CIF-B) or transforming growth factor beta 2 (TGF- beta 2) that is found in bone and has heretofore been identified as having in vitro cartilage-inducing activity, TGF- beta activity, and anti-inflammatory activity has now been found to possess potent ...


4
Mcpherson John M: Treatment with kallikrein inhibitors. Genzyme Corporation, Mcpherson John M, LISSY Natalie A, February 26, 2009: WO/2009/026334 (9 worldwide citation)

Methods, kits and compositions are disclosed that include a non-naturally occurring kallikrein inhibitor and optionally a viscosupplement for the treatment of joint pathology.


5
Mcpherson John M, Yaeger Peter C, Brown Marie E, Hanlon James G, Binette Francois: Chondrocyte media formulations and culture procedures. Genzyme, June 9, 1999: EP0920490-A2 (8 worldwide citation)

One object of the present invention is based upon the development and use of a serum-free defined cell culture medium comprising a supplement mixture, a component mixture, a vitamin mixture, an inorganic salt mixture and amino acid mixture that avoids the problems inherent in the use of serum. In pa ...


6
Wallace Donald G, Piez Karl A, Smestad Thomas L, Armstrong Rosa, Seyedin Saeid, Mcpherson John M: Bone repair using collagen.. Collagen, May 29, 1991: EP0429438-A2 (8 worldwide citation)

A composition for repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted fibrillar skin collagen is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be lyophilized and used in the form of mats ...


7
Mcpherson John M, Yaeger Peter C, Brown Marie E, Hanlon James G, Binette Francois: Formulations de milieux de culture de chondrocytes et procedes de culture, Chondrocyte media formulations and culture procedures. Genzyme Corporation, Genzyme Corporation, GOWLING LAFLEUR HENDERSON, February 5, 1998: CA2261292 (8 worldwide citation)

One object of the present invention is based upon the development and use of a serum-free defined cell culture medium comprising a supplement mixture, a component mixture, a vitamin mixture, an inorganic salt mixture and amino acid mixture that avoids the problems inherent in the use of serum. In pa ...


8
Mcpherson John M, Edmunds Tim, Zhou Qun: Antibody-based therapeutics with enhanced adcc activity. Genzyme Corporation, Mcpherson John M, Edmunds Tim, Zhou Qun, MCDONELL Leslie A, April 26, 2007: WO/2007/048122 (7 worldwide citation)

Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose- type N/-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for t ...


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Kaplan Johanne, Mcpherson John M: Methods of treating autoimmune diseases. Genzyme Corporation, Kaplan Johanne, Mcpherson John M, MCDONELL Leslie A, October 25, 2007: WO/2007/121233 (3 worldwide citation)

Methods for treating patients with autoimmune diseases are disclosed. The methods of the application include first depleting circulating lymphocytes in the mammal, e.g., by administering anti-thymocyte antibody, and then, during the course of repopulation, administering to the mammal a therapeutical ...