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Bierer Donald, Mcclure Andrea, Fu Wenlang, Achebe Furahi, Ladouceur Gaetan H, Burke Michael J, Bi Cheng, Hart Barry, Dumas Jacques, Sibley Robert, Scott William J, Johnson Jeffrey, Asgari Davoud: 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors. Bayer Pharmaceuticals, June 30, 2004: EP1432706-A2

The invention provides novel substituted 3-pyridyl tetrazoles and pharmaceutical compositions thereof. The invention also provides methods of use of these materials and pharmaceutical compositions as inhibitors of lyases, e.g., the 17a-hydroxylase-C17,20 enzyme. The invention further provides method ...


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Dixon Julie A, Brennan Catherine, Miranda Karl, Chandler Brent, Phillips Barton, Fan Jianmei, Brands Michael, Mcclure Andrea, Jones Benjamin, Fu Wenlang, Bierer Donald, Magnuson Steven, Kluender Harold C E: Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis. Bayer Pharmaceuticals, March 28, 2007: EP1765823-A1

This invention relates to pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.


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O& 039, Connor Stephen J, Dumas Jacques, Lee Wendy, Dixon Julie, Cantin David, Gunn David, Burke Jennifer, Phillips Barton, Lowe Derek, Shelekhin Tatiana, Wang Gan, Ma Xin, Ying Shihong, Mcclure Andrea, Achebe Furahi, Lobell Mario, Ehrgott Frederick, Iwuagwu Christiana, Parcella Kyle: Pyrrolo[2,1-f] [1,2,4] triazin-4-ylamines igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases. Bayer Healthcare, July 23, 2008: EP1945222-A2

This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.


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Bierer Donald, Mcclure Andrea, Fu Wenlang, Achebe Furahi, Ladouceur Gaetan H, Burke Michael J, Bi Cheng, Hart Barry, Dumas Jacques, Sibley Robert, Scott William J, Johnson Jeffrey, Asgari Davoud: 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors. Bayer Pharmaceuticals Corporation, Bierer Donald, Mcclure Andrea, Fu Wenlang, Achebe Furahi, Ladouceur Gaetan H, Burke Michael J, Bi Cheng, Hart Barry, Dumas Jacques, Sibley Robert, Scott William J, Johnson Jeffrey, Asgari Davoud, GREENMAN Jeffrey M, April 3, 2003: WO/2003/027085

The invention provides novel thiazoles bearing 3-pyridyl or 4-isoquinilinyl substituents, and pharmaceutical compositions thereof. The invention also provides methods of using compounds of the invention and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17a-hydroxylase-C17,20 ...