1
Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to enhance processivity of telomerase. Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114064 (50 worldwide citation)

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the preparation of a medicament for enhancing the processivity of a telomerase increasing the number of mitotic cycles and mitotic cell division.


2
Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to inhibit neoplasia. Institute Of Organic Chemistry And Biochemistry A Cademy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114065 (49 worldwide citation)

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the manufacture of a medicament for inhibiting an enzyme that causes neoplasia in an animal (e.g. a human) and enhancing the processivity of a telomerase.


3
Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to enhance processivity of telomerase. Acad Of Science Czech Republic, January 23, 2008: EP1879657-A2

The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the preparation of a medicament for enhancing the processivity of a telomerase.



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