1

2

3
Beigelman Leonid, Beaudry Amber, Matulic Adamic Jasenka, Burgin Alex, Karpeisky Alexander, Sweedler David: Nucleoside triphosphates and their incorporation into ribozymes. Ribozyme Pharm, January 5, 2005: EP1493818-A2 (7 worldwide citation)

Novel nucleotide triphosphates, methods of synthesis and process of incorporating these nucleotide triphosphates into oligonucleotides, and isolation of novel nucleic acid catalysts (e.g. ribozymes) are disclosed.


4
BEIGELMAN LEONID, MATULIC ADAMIC JASENKA, VARGEESE CHANDRA, KARPEISKY ALEXANDER, SHAFFER CHRISTOPHER, BLATT LAWRENCE: Conjugates and compositions for cellular delivery, Konjugate und Zusammensetzungen zur zellulären Verabreichung, Conjugués et compositions pour la fourniture cellulaire. SIRNA THERAPEUTICS, February 8, 2012: EP2415486-A2 (6 worldwide citation)

This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including folate, galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin (HAS) derived conjugates of biologically active compounds, incl ...


5

6
Beigelman Leonid, Matulic Adamic Jasenka, Vargeese Chandra, Karpeisky Alexander, Blatt Lawrence, Shaffer Christopher: Conjugates and compositions for cellular delivery. Sirna Therapeutics, September 14, 2005: EP1572067-A2 (6 worldwide citation)

This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including folate, galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin (HAS) derived conjugates of biologically active compounds, incl ...


7

8
Usman Nassim, Wincott Francine E, Matulic Adamic Jasenka, Beigelman Leonid: Non-nucleotide containing enzymatic nucleic acid. Ribozyme Pharmaceuticals, WARBURG Richard J, March 9, 1995: WO/1995/006731 (4 worldwide citation)

Enzymatic nucleic acid molecule containing one or more non-nucleotide mimetics, and having activity to cleave an RNA or DNA molecule.


9
Beigelman Leonid, Stinchcomb Daniel T, Jarvis Thale, Draper Kenneth, Pavco Pamela, Mcswiggen James, Gustofson John, Usman Nassim, Wincott Francine, Matulic Adamic Jasenka, Karpeisky Alexander, Thompson James D, Modak Anil, Burgin Alex: Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses. Ribozyme Pharmaceuticals, sWARBURG Richard J, June 20, 1996: WO/1996/018736 (4 worldwide citation)

An enzymatic nucleic acid molecule which cleaves RNA associated with development or maintenance of an arthritic condition, induction of graft tolerance or reversal of an immune response. In particular, the ribozyme sequences are directed to an mRNA encoding B7-1, B7-2, B7-3, CD40 and/or stromelysin. ...


10
Usman Nassim, Wincott Francine E, Matulic Adamic Jasenka: Abasic moieties containing enzymatic nucleic acids. Ribozyme Pharm, October 30, 2002: EP1253199-A1 (1 worldwide citation)

The invention relates to enzymatic nucleic acid molecules having enzymatic activity to cleave a target RNA molecule, wherein said enzymatic nucleic acid molecule comprises one or more abasic moieties in a single-stranded region of said enzymatic nucleic acid molecule.