1
Christopher Hulme, George C Morton, Joseph M Salvino, Richard F Labaudiniere, Helen J Mason, Matthew M Morrissette, Liang Ma, Marie Pierre Cherrier: Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds. Aventis Pharamaceuticals, George G Wang, Irving Newman, December 10, 2002: US06492553 (11 worldwide citation)

A method for preparing a N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that are useful for preparing such compounds.


2
Robert D Groneberg, Kent W Neuenschwander, Stevan W Djuric, Gerald M McGeehan, Christopher J Burns, Steven M Condon, Matthew M Morrissette, Joseph M Salvino, Anthony C Scotese, John W Ullrich: Substituted (aryl, heteroaryl, arylmethyl or heteroarylmethyl) hydroxamic acid compounds. Rhone Poulenc Rorer Pharmaceuticals, Raymond S Parker III, May 2, 2000: US06057369 (10 worldwide citation)

This invention is directed to compounds of formula I: ##STR1## wherein the variables are as described herein. Compounds within the scope of the present invention possess useful properties, more particularly pharmaceutical properties. They are especially useful for inhibiting the production or physio ...


3

4
Matthew M Morrissette, Peter D Williams, John S Wai, Thorsten E Fisher, Terry A Lyle: HIV integrase inhibitors. Merck & Co, Kenneth R Walton, Sheldon O Heber, November 17, 2009: US07619086 (3 worldwide citation)

Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein Z, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS ...


5
Peter D Williams, Terry A Lyle, Matthew M Morrissette, Lekhanh O Tran, Donnette D Staas: Thrombin inhibitors. Merck & Co, Richard S Parr, Valerie J Camara, March 4, 2003: US06528503 (3 worldwide citation)

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure:


6

7
Wei Han, Melissa Egbertson, John S Wai, Linghang Zhuang, Rowena D Ruzek, Debra S Perlow, Richard CA Isaacs, Mark Cameron, Bruce S Foster, Ulf H Dolling, R Scott Hoermer, Vanessa E Obligado, Lou Anne Neilson, Boyoung Kim, Linda S Payne, Matthew M Morrissette, Peter D Williams, Philip J Pye, Remy Angelaud, Danny E Mancheno, David Askin: Hiv integrase inhibitors. Merck And Co, August 2, 2007: US20070179196-A1

Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R,1?, R,2?, R,3?, R,4? and R,5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the preve ...


8
Philip Jones, Peter D Williams, Matthew M Morrissette, Michelle Sparks Kuo, Joseph P Vacca: N-benzyl-3,4-dihyroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4- carboxamide compounds useful as hiv integrase inhibitors. Istituto Di Ricerche Di Biologia Molecolare P Angeletti, Merck & Co, Merck And Co, July 5, 2007: US20070155744-A1

N-Benzyl-dihydroxypyridine carboxamide compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dihydroxypyridine carboxamides are of Formula (I) wherein Q is Formula (II) or Formula (III); T is Formula (IV); and R1, R2, X1,X2,X3, and Y1 are defined herein. ...


9
Peter D Williams, Terry A Lyle, Matthew M Morrissette, Lekhanh O Tran, Donnette D Staas: Thrombin inhibitors. Merck And Co, January 16, 2003: US20030013700-A1

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: 1 or a pharmaceutically acceptable salt thereof, e.g. 1-(3(S)-Cyclopropyl-2(R)-hydroxybutanoyl)azetidine-2(S)-N-(2-aminomethyl-5-chlorobenzyl)carboxamide, and 1-(3-Cyclop ...


10
Harold G Selnick, James C Barrow, Philippe G Nantermet, Peter D Williams, Kenneth J Stauffer, Philip E Sanderson, Kenneth E Rittle, Matthew M Morrissette, Catherine M Wiscount, Lekhanh O Tran, Terry A Lyle, Donnette D Staas: Thrombin inhibitors. Merck And Co, August 29, 2002: US20020119992-A1

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: 1 or a pharmaceutically acceptable salt thereof, e.g. where R3 is —CH2NH2, —CH2CH2NH2, or —CH2NHC(O)OC(CH3)3.