1
Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Clark Richard, Ikuta Hironori, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, Aoki Mika: Xanthine derivatives as dpp-iv inhibitors. Eisai, August 27, 2003: EP1338595-A2 (68 worldwide citation)

The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R, R, R, R, R, R, R, R, R, R, R, and R each represent a hydrogen atom; X represents an alkynyl group, an aryl group, and such, w ...


2
Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Richard Clark, Ikuta Hironori, Kira Kazunobu, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto: Novel fused imidazole derivative. Eisai, March 16, 2005: EP1514552-A1 (57 worldwide citation)

The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substi ...


3
Shinoda Masanobu, Emori Eita, Matsuura Fumiyoshi, Kaneko Toshihiko, Ohi Norihito, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Miyashita Sadakazu, Hibara Taro, Seiki Takashi, Clark Richard, Harada Hitoshi: Carboxylic acid derivatives and drugs containing the same. Eisai, June 26, 2002: EP1216980-A1 (25 worldwide citation)

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin-resistant improver, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the follow ...


4
Miyashita Sadaichi, Shinoda Masanobu, Hiyoshi Hironobu, Matsuura Fumiyoshi: Agent for promoting elevation of hdl level. Eisai, July 2, 2004: JP2004-182657 (17 worldwide citation)

PROBLEM TO BE SOLVED: To provide a compound targeting prevention and treatment of a disease accompanied by arteriosclerosis, accompanying the elevation of HDL and not accompanying the elevation of TG.SOLUTION: The agent for promoting the elevation of an HDL level in plasma contains a carboxylic acid ...


5
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro, Harada Hitoshi, Ohashi Kaya: Carboxylic acid derivative and salt thereof. Eisai, January 14, 2004: EP1380562-A1 (14 worldwide citation)

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following form ...


6
Suzuki Shuichi, Kotake Makoto, Miyamoto Mitsuaki, Kawahara Tetsuya, Kajiwara Akiharu, Hishinuma Ieharu, Okano Kazuo, Miyazawa Syuhei, Clark Richard, Ozaki Fumihiro, Sato Nobuaki, Shinoda Masanobu, Kamada Atsushi, Tsukada Itaru, Matsuura Fumiyoshi, Naoe Yoshimitsu, Terauchi Taro, Oohashi Yoshiaki, Ito Osamu, Tanaka Hiroshi: 2-iminopyrrolidine derivates. Eisai, February 25, 2004: EP1391451-A1 (13 worldwide citation)

A 2-iminopyrrolidine derivative represented by the formula: äwherein ring B represents a benzene ring, pyridine ring, etc.; R - R represent hydrogen, halogen, C1-6 alkyl, etc.; R represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, ...


7
Suzuki Shuichi, Kotake Makoto, Miyamoto Mitsuaki, Kawahara Tetsuya, Kajiwara Akiharu, Hishinuma Ieharu, Okano Kazuo, Miyazawa Syuhei, Clark Richard, Ozaki Fumihiro, Sato Nobuaki, Shinoda Masanobu, Kamada Atsushi, Tsukada Itaru, Matsuura Fumiyoshi, Naoe Yoshimitsu, Terauchi Taro, Oohashi Yoshiaki, Ito Osamu, Tanaka Hiroshi: 2-iminoimidazole derivatives (1). Eisai, March 3, 2004: EP1394152-A1 (5 worldwide citation)

A 2-iminoimidazole derivative represented by the formula: äwherein ring C represents a benzene ring, a pyridine ring, etc.; R represents optionally substituted C1-6 alkyl, etc.; R represents hydrogen, halogen, acyl, etc. ; R represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y represents ...


8
Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Richard Clark, Ikuta Hironori, Kira Kazunobu, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto: Novel fused imidazole derivative. Eisai, Yoshikawa Seiji, Emori Eita, Matsuura Fumiyoshi, Richard Clark, Ikuta Hironori, Kira Kazunobu, Yasuda Nobuyuki, Nagakura Tadashi, Yamazaki Kazuto, SHIMIZU Hatsushi, December 18, 2003: WO/2003/104229 (5 worldwide citation)

A compound represented by the general formula (I) [wherein T1 means an optionally substituted, monocyclic or bicyclic, 4- to 12-membered, heterocyclic group containing one or two nitrogen atoms in the ring; X means optionally substituted C1-6 alkyl, etc.; Z1 and Z2 each independently means nitrogen ...


9
Clark Richard, Matsuura Fumiyoshi, Kira Kazunobu, Hirota Shinsuke, Azuma Hiroshi, Nagakura Tadashi, Horizoe Tatsuo, Tabata Kimiyo, Kusano Kazutomi, Omae Takao, Inoue Atsushi: (Ja) トリアゾロン誘導体, (En) Triazolone derivative. Eisai R & D Management, Clark Richard, Matsuura Fumiyoshi, Kira Kazunobu, Hirota Shinsuke, Azuma Hiroshi, Nagakura Tadashi, Horizoe Tatsuo, Tabata Kimiyo, Kusano Kazutomi, Omae Takao, Inoue Atsushi, HASEGAWA Yoshiki, October 4, 2007: WO/2007/111212 (4 worldwide citation)

(EN) Compounds of the general formula (1), salts thereof and their hydrates. (1) In the formula, each of R1a, R1b, R1c and R1d independently is a hydrogen atom, etc. R2 is an optionally substituted phenyl, etc. R3 is an optionally substituted C6-10 aryl, etc. Each of Z1 and Z2 independently is a hyd ...


10
Matsuura Fumiyoshi, Emori Eita, Shinoda Masanobu, Clark Richard, Kasai Shunji, Yoshitomi Hideki, Yamazaki Kazuto, Inoue Takashi, Miyashita Sadakazu, Hihara Taro: Carboxylic acid derivative and medicine comprising salt or ester of the same. Eisai, March 3, 2004: EP1394147-A1 (2 worldwide citation)

The present invention provides novel carboxylic acid derivatives useful as an insulin sensitizer, a salt thereof or a hydrate of them, and a medicament comprising the derivative as the active ingredient. Specifically, it provides a carboxylic acid derivative represented by the following formula: (wh ...