1
James Aggen, John H Griffin, Mathai Mammen, Daniel Marquess, Edmund J Moran, David Oare: Muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Joyce G Cohen, February 17, 2004: US06693202 (123 worldwide citation)

Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modu ...


2
Mathai Mammen, David Oare: Therapeutic ureas. Theravance, Jeffrey A Hagenah, David E Boone, October 21, 2003: US06635764 (76 worldwide citation)

This invention relates to urea compounds that are muscarinic receptor antagonists and agonists, pharmaceutical compositions comprising such compounds, and methods of preparing these compounds.


3
Mathai Mammen, Sarah Dunham, Adam Hughes, Tae Weon Lee, Craig Husfeld, Eric Stangeland, Yan Chen: Biphenyl derivatives. Theravance, Jeffrey A Hagenah, November 28, 2006: US07141671 (65 worldwide citation)

This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor a ...


4

5
Mathai Mammen, Sarah Dunham: adrenergic receptor agonist and muscarinic receptor antagonist activity, Compounds having β. Theravance, Jeffrey A Hagenah, Connie C Tong, March 18, 2008: US07345060 (34 worldwide citation)

The invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7a, R7b, W, G1, G2, a, b, c, d and m are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention is also directed to pharmaceutical compositions comp ...


6
Mathai Mammen, Yu Hua Ji, YongQi Mu, Craig Husfeld, Li Li: Biphenyl compounds useful as muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Shelley Eberle, October 30, 2007: US07288657 (34 worldwide citation)

This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compo ...


7
Mathai Mammen, Yu Hua Ji, YongQi Mu, Craig Husfeld, Li Li: Biphenyl compounds useful as muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Shelley Eberle, September 4, 2007: US07265133 (30 worldwide citation)

This invention provides compounds of formula I: wherein a, b, c, m, p, s, t, W, Ar1, X1, R1, R2, R3, R4, R6, and R7 are as defined specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, process ...


8
Mathai Mammen, Yu Hua Ji, YongQi Mu, Eric L Stangeland, Aaron Kushner, Craig Husfeld: Biphenyl compounds useful as muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Shelley Eberle, August 28, 2007: US07262205 (27 worldwide citation)

This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, pr ...


9
Yu Hua Ji, Craig Husfeld, Mathai Mammen, YongQi Mu, Eric L Stangeland: Biphenyl compounds useful as muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Shelley Eberle, January 20, 2009: US07479562 (23 worldwide citation)

The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermed ...


10
Mathai Mammen, Yu Hua Ji, YongQi Mu, Trevor Mischki, Viengkham Malathong: Biphenyl compounds useful as muscarinic receptor antagonists. Theravance, Jeffrey A Hagenah, Shelley Eberle, November 25, 2008: US07456199 (22 worldwide citation)

This invention provides compounds of formula I: wherein a, b, c, m, p, s, t, W, Ar1, X1, R1, R2, R3, R4, R6, and R7 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, ...



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