1
Masanobu Shinoda, Eita Emori, Fumiyoshi Matsuura, Toshihiko Kaneko, Norihito Ohi, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Sadakazu Miyashita, Taro Hibara, Takashi Seiki, Richard Clark, Hitoshi Harada: Carboxylic acid derivatives and drugs containing the same. Eisai, Birch Stewart Kolasch & Birch, April 26, 2005: US06884821 (23 worldwide citation)

Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R1 is hydrogen, hydroxyl, alkyl, or the like; L is a sin ...


2
Shuichi Suzuki, Makoto Kotake, Mitsuaki Miyamoto, Tetsuya Kawahara, Akiharu Kajiwara, Ieharu Hishinuma, Kazuo Okano, Syuhei Miyazawa, Richard Clark, Fumihiro Ozaki, Nobuaki Sato, Masanobu Shinoda, Atsushi Kamada, Itaru Tsukada, Fumiyoshi Matsuura, Yoshimitsu Naoe, Taro Terauchi, Yoshiaki Oohashi, Osamu Ito, Hiroshi Tanaka, Takashi Musya, Motoji Kogushi, Tsutomu Kawada, Toshiyuki Matsuoka, Hiroko Kobayashi, Ken ichi Chiba, Akifumi Kimura, Naoto Ono: 2-iminopyrrolidine derivatives. Eisai, Andrea L C Robidoux, Choate Hall & Stewart, July 17, 2007: US07244730 (15 worldwide citation)

A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101–R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarb ...


3
Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Richard Clark, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara: Benzene compound and salt thereof. Eisai, Birch Stewart Kolasch & Birch, July 17, 2007: US07244861 (11 worldwide citation)

The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the following formula, a salt thereof or a hyd ...


4
Masahiro Tanigawa, Masanobu Shinoda, Jun Odahara, Tsuguo Hoshikawa: Vehicle including electric folding roof. Honda Giken Kogyo Kabushiki Kaisha, Mitsui Kinzoku Kogyo Kabushiki Kaisha, Merchant & Gould P C, September 4, 2001: US06283531 (11 worldwide citation)

A vehicle comprises a vehicle body, an electric folding roof housed in the vehicle body in a folded state, an electric motor operate to unfold the folded electric folding roof, and a rigid roof designed to be attached to the vehicle body when the electric folding roof is folded and housed in the veh ...


5
Shuichi Suzuki, Makoto Kotake, Mitsuaki Miyamoto, Tetsuya Kawahara, Akiharu Kajiwara, Ieharu Hishinuma, Kazuo Okano, Syuhei Miyazawa, Richard Clark, Fumihiro Ozaki, Nobuaki Sato, Masanobu Shinoda, Atsushi Kamada, Itaru Tsukada, Fumiyoshi Matsuura, Yoshimitsu Naoe, Taro Terauchi, Yoshiaki Oohashi, Osamu Ito, Hiroshi Tanaka, Takashi Musha, Motoji Kogushi, Tsutomu Kawata, Toshiyuki Matsuoka, Hiroko Kobayashi, Ken ichi Chiba, Akifumi Kimura, Naoto Ono: 2-iminoimidazole derivatives (2). Eisai R&D Management, Robin A Weatherhead, Choate Hall & Stewart, December 4, 2007: US07304083 (5 worldwide citation)

A 2-iminoimidazole derivative represented by the formula: {wherein R1, R2 and R3 represent hydrogen, optionally substituted C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar rep ...


6
Richard Clark, Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara: Cyclic compound and PPAR agonist. Eisai, Birch Stewart Kolasch & Birch, May 13, 2008: US07371777 (5 worldwide citation)

The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. Wherein a, b and c are the same as or different from one another and each re ...


7
Hitoshi Harada, Masanobu Shinoda, Richard Clark, Fumiyoshi Matsuura, Eita Emori, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara: Carboxylic acids. Eisai, Birch Stewart Kolasch & Birch, August 7, 2007: US07253178 (3 worldwide citation)

The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formul ...


8
Yasushi Okamoto, Katsuya Tagami, Shigeki Hibi, Hirotoshi Numata, Tetsuya Kawahara, Naoki Kobayashi, Masanobu Shinoda, Koukichi Harada, Kaname Miyamoto, Koichi Abe: Quinone derivatives. Eisai, Flynn Thiel Boutell & Tanis, July 12, 1994: US05329010 (2 worldwide citation)

The present invention is a quinone derivative which exhibits excellent therapeutic activity represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein A stands for a group represented by the formula: ##STR2## (wherein R.sup.3, R.sup.4 and R.sup.5 is the s ...


9
Shuichi Suzuki, Masanobu Shinoda, Motoji Kogushi, Hiroko Kobayashi: Cyclic amidine derivatives. EISAI R&D Management, Andrea L C Robidoux, Choate Hall & Stewart, January 13, 2009: US07476688 (1 worldwide citation)

A cyclic amidine derivative represented by the formula: [wherein R1, R2 and R3 represent hydrogen, C1-6 alkyl, aryl-C1-6 alkyl, etc.; R4, R5 and R7 represent hydrogen, C1-6 alkyl, etc.; Z represents 0 or 1; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; n represents 1 or 2; Y1 repr ...


10
Fumiyoshi Matsuura, Eita Emori, Masanobu Shinoda, Richard Clark, Shunji Kasai, Hideki Yoshitomi, Kazuto Yamazaki, Takashi Inoue, Sadakazu Miyashita, Taro Hihara, Hitoshi Harada, Kaya Ohashi: Carboxylic acid derivative and salt thereof. Eisai R&D Management, Birch Stewart Kolasch & Birch, June 9, 2009: US07544835 (1 worldwide citation)

Carboxylic acid compound or salt or hydrate thereof useful as insulin sensitizer, represented by the formula wherein R1 represents hydrogen, hydroxyl, halogen, carboxyl, or C1-6 alkyl, L represents single bond or C1-6-alkylene, C2-6-alkenylene, or C2-6-alkynylene, M represents single bond or C1-6-al ...