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Tohru Kino, Motoaki Nishikawa, Masami Ezaki, Sumio Kiyoto, Masakuni Okuhara, Shigehiro Takase, Satoshi Okada, Nobuharu Shigematsu: Process for producing WS-9326A and WS-9326B. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, July 25, 1995: US05436140 (3 worldwide citation)

The novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof have useful pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain. A method for the production of the peptides WS-9326A and WS-9326B and derivatives ther ...


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Satoshi Ueda, Miho Tanaka, Masami Ezaki, Kazutoshi Sakamoto, Seiji Hashimoto, Nobutaka Oohata, Masaru Tsuboi, Michio Yamashita: Cyclic lipopeptide acylase. Fukisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, November 14, 2000: US06146872 (3 worldwide citation)

The present invention provides a cyclic lipopeptide acylase which may effectively deacylate the acyl side chain of a cyclic lipopeptide compound, specifically FR901379 Substance or its analog thereof shown by the following general formula [I], and a process for production of a cyclic peptide compoun ...


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Satoshi Ueda, Miho Tanaka, Masami Ezaki, Kazutoshi Sakamoto, Seiji Hashimoto, Nobutaka Oohata, Masaru Tsuboi, Michio Yamashita: Process for the deacylation of cyclic lipopeptides. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, March 27, 2001: US06207434 (2 worldwide citation)

There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the general formula [I] with effectiveness as well a method of producing a cyclic peptide compound which comprises ...


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Tohru Kino, Motoaki Nishikawa, Masami Ezaki, Sumio Kiyoto, Masakuni Okuhara, Shigehiro Takase, Satoshi Okada, Nobuharu Shigematsu: Peptides WS-9326a and WS-9326b, derivatives thereof and uses thereof. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, June 8, 1993: US05217952 (1 worldwide citation)

This invention relates to the novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof which have pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain.


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Masakuni Okuhara, Toshio Goto, Masami Ezaki, Miho Tanaka, Shigehiro Takase, Hidenori Nakajima, Hideo Hirai, Akira Katayama: Amino acid derivatives of antitumor activity. Fujisawa Pharmaceutical, Oblon Spivak McCelland Maier & Neustadt, July 3, 1990: US04939241 (1 worldwide citation)

The invention relates to compounds of antitumor activity of the formula: ##STR1## ps in which R.sup.1 is hydrogen, lower allkyl, halo(lower)alkyl or aryl,


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Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara, Shigehiro Takase: WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use for treatment of pulmonary emphysema and adult respiratory distress syndrome. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, December 1, 1992: US05167958 (1 worldwide citation)

A method of treating pulmonary emphysema or adult respiratory distress syndrome in a subject in need thereof which comprises administering to the subject an effective amount of WS7622A, B, C and/or D, derivatives thereof, or their pharmaceutically acceptable salt.


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Michiyo Miyauchi, Eisaku Tsujii, Masami Ezaki, Seiji Hashimoto, Masakuni Okuhara: Antimicrobial agent, FR109615 and production thereof. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, May 7, 1996: US05514715

A method of killing pathogenic fungi by contacting them with an effective amount of (1R,2S)-2-aminocyclopentanecarboxylic acid (FR109615) or a salt thereof.


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Kozo Ochi, Masami Ezaki, Morita Iwami, Tadaaki Komori, Masanobu Kohsaka: FR-900493 substance, a process for its production and a pharmaceutical composition containing the same. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, August 21, 1990: US04950605

FR-900493 is a compound of molecular formula C.sub.20 H.sub.33 N.sub.5 O.sub.11 which may be recovered from Bacillus cultures, possesses antimicrobial activity, and may be used for the treatment and prevention of infectious diseases in humans and animals.