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Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka: Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, January 16, 1990: US04894366 (104 worldwide citation)

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a pr ...


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Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka: Method for immunosuppression. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, May 29, 1990: US04929611 (58 worldwide citation)

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a pr ...


3
Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara, Kazuo Sakane, Kohji Kawabata, Hidenori Ohki: Cyclic polypeptide with antibiotic activity, process for its preparation and pure culture of a coelomycetes strain.. Fujisawa Pharmaceutical Co, December 27, 1991: EP0462531-A2 (36 worldwide citation)

A polypeptide compound of the following general formula : wherein R is hydrogen or acyl group, R is hydroxy or acyloxy, R is hydrogen or hydroxysulfonyloxy, and R is hydrogen or carbamoyl, with proviso that (i) R is acyloxy, when R is hydrogen, and (ii) R is not palmitoyl, when R is hydroxy, R is hy ...


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Masakuni Okuhara, Toshio Goto, Yasuhiro Hori, Takashi Fujita, Hirotsugu Ueda, Nobuharu Shigematsu: FR901228 substance and preparation thereof. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, December 11, 1990: US04977138 (35 worldwide citation)

The invention relates to a compound having antimicrobial and antitumor activity, the compound being designated FR901228 substance of the following formula: ##STR1##


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Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka: Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, September 11, 1990: US04956352 (28 worldwide citation)

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a pr ...


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Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka: Strain of Streptomyces for the production of tricyclo compounds. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt P C, April 29, 1997: US05624842 (13 worldwide citation)

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a pr ...


9
Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka: Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same. Fujisawa Pharmaceutical Company, Oblon Spivak McClelland Maier & Neustadt, May 5, 1992: US05110811 (13 worldwide citation)

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a pr ...


10
Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka: Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same. Fujisawa Pharmaceutical, Oblon Spivak McClelland Maier & Neustadt, March 5, 1996: US05496727 (8 worldwide citation)

This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a pr ...