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Kimio Mizuno, Tetsuo Matsuda, Katsumi Asano, Akira Yagi, Masaki Takada, Tetsu Saito, Minoru Toriya, Shuzo Satoi, Kazuo Matsuura: Antibiotic aculeacins. Toyo Jozo Kabushiki Kaisha, Young & Thompson, August 31, 1976: US03978210 (39 worldwide citation)

A family of antibiotics active against pathogenic yeasts and fungi comprises aculeacin-A, -B, -C, -D, -E, -F, and -G. These are produced from cultured broth of Aspergillus aculeatus FERM-P 2324.


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Hideo Sakakibara, Shuzo Satoi, Masashi Awata, Hitoshi Sagai, Mitsuo Hayashi, Naoki Muto, Masaki Takada: Aminoglycoside antibiotic saccharocins. Toyo Jozo Kabushiki Kaisha, Young & Thompson, November 13, 1984: US04482707 (13 worldwide citation)

Antibiotic saccharocins of the formula ##STR1## wherein R is hydrogen (saccharocin) or hydroxyl (3'-oxysaccharocin) are produced by culturing a microorganism belonging to the genus Saccharopolyspora, for example Saccharopolyspora sp. AC 3440 FERM-P No. 6238, in a conventional nutrient medium, and se ...


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Mamoru Takahashi, Shigeyuki Imamura, Masaki Takada: Novel bilirubin oxidase which has a substrate specifity to bilirubin, but not to biliverdin, catechol and hemin. Toyo Jozo Kabushiki Kaisha, Young & Thompson, January 15, 1991: US04985360 (9 worldwide citation)

A novel bilirubin oxidase is provided having a substrate specificity for bilirubin but not to, at least, biliverdin, catechol and hemin and which catalyzes the enzyme reaction between two moles of bilirubin and one mole of oxygen to yield two moles of biliverdin and two moles of water. A process is ...


5
Satoshi Yaginuma, Akira Asahi, Masaki Takada, Mitsuo Hayashi, Kiyofumi Fukukawa: Enzyme Inhibiting substance. Toyo Jozo, Antonelli Terry and Wands, March 22, 1988: US04732910 (7 worldwide citation)

A substance is provided which has strong enzyme inhibitory activity against thiol proteases such as papain, ficin, bromelain, etc. and which is represented by the following formula: ##STR1## (wherein R is a hydrogen atom or a hydroxyl group), its pharmaceutically acceptable salt or hydrate.


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Eiichi Yoshino, Hidehiko Ishikawa, Fumitaka Inoue, Masaki Takada, Hideo Misaki: Process for producing L-amino acid oxidase. Toyo Jozo Company, Wyatt Gerber Shoup Scobey & Badie, November 2, 1982: US04357425 (4 worldwide citation)

L-amino acid oxidase is obtained by culturing a microorganism which can produce L-amino acid oxidase and belongs to the genus Colletotrichum, e.g. Colletotrichum sp. M5073, deposition number FERMP 5441, in a culturing medium and recovering the oxidase from cells of the microorganism.


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Hideo Sakakibara, Masashi Awata, Shuzo Satoi, Naoki Mutoh, Masaki Takada, Mitsuo Hayashi: Antibiotic acmimycin and its production. Toyo Jozo Kabushiki Kaisha, Young & Thompson, May 14, 1985: US04517296 (3 worldwide citation)

Antibiotic acmimycin of the formula ##STR1## is active against Gram positive and Gram negative bacteria. It is produced by culturing the microorganism Streptomyces sp. AC4559 FERM P-6445, and isolating the above compound from the cultured medium.


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Satoshi Yaginuma, Akira Asahi, Masaki Takada: Physiologically-active novel substance "Aldostatin" and production method thereof. Toyo Jozo, Oblon Fisher Spivak McClelland & Maier, June 7, 1988: US04749571 (2 worldwide citation)

A physiologically-active novel substance "aldostatin" having an estimated molecular formula of C.sub.20 H.sub.20 N.sub.2 O.sub.8 is produced by culturing an aldostatin-producing microorganism of the Pseudeurotium, for example, the Pseudeurotium zonatum M4109 strain. Aldostatin inhibits the aldose re ...


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Satoshi Yaginuma, Masashi Awata, Masaki Takada, Kenji Kinoshita: Physiologically active substance TPI and production thereof. Toyo Jozo Kabushiki Kaisha, Young & Thompson, January 31, 1989: US04801697 (2 worldwide citation)

A compound of the formula ##STR1## wherein R is .beta.-D-glucopyranosyl, .beta.-D-galactopyranosyl, 6'-O-acetyl-.beta.-D-glucopyranosy or 6'-O-acetyl-.beta.-D-galactopyranosyl, or a pharmaceutically acceptable salt thereof, has bronchodilator, cardiac activity, smooth muscle relaxant activity and ho ...


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Masaki Takada, Atsushi Takada, Satoru Iwasaki: Medium processing device and medium transaction device. Oki Electric, Rabin & Berdo P C, March 14, 2017: US09595154 (1 worldwide citation)

A medium processing device including: a main tape having one end fixed to a drum, and being wound onto the drum while sandwiching a medium with the drum; a first roller at which the main tape unwound from a main reel is turned back at a distant location from the drum; a second roller at which the ma ...