1
Maryanoff Cynthia A, Villani Frank J, Raffa Robert B: A tramadol n-oxide material, enantiomers and compositions thereof, and their use.. Mcneilab, March 17, 1993: EP0532348-A2 (38 worldwide citation)

This invention relates to a tramadol N-oxide material, enantiomers and compositions thereof and their use. The tramadol N-oxide material and compositions thereof are pharmacologically useful in treating pain, diarrhea and tussive conditions. The tramadol N-oxide is also subject to less side-effects ...


2
Maryanoff Cynthia A, Six Karel, Vandecruys Roger: Solvent free amorphous rapamycin. Cordis Corporation, Maryanoff Cynthia A, Six Karel, Vandecruys Roger, JOHNSON Philip S, March 9, 2006: WO/2006/026531 (10 worldwide citation)

An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. The stability of the therapeutic agents may be improved by creating substantially solvent-free, amorphous forms of the therapeut ...


3
Maryanoff Cynthia A, Six Karel Pieter Laura Stefaan, Vandecruys Roger Petrus Gerebern: Pharmaceutical dosage forms of stable amorphous rapamycin like compounds. Cordis Corporation, Maryanoff Cynthia A, Six Karel Pieter Laura Stefaan, Vandecruys Roger Petrus Gerebern, JOHNSON Philip S, April 13, 2006: WO/2006/039237 (3 worldwide citation)

The present invention provides a pharmaceutical dosage form comprising stable amorphous rapamycin like compounds and a pharmaceutically acceptable excipient and methods of making the pharmaceutical dosage form.


4
Maryanoff Cynthia A, Sorgi Kirk L, Scott Lorraine: Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-o-(1-methylethylidene)-beta-d-fructopyranose and (1-methylcyclohexyl)methanol.. Mcneilab, March 24, 1993: EP0533483-A2 (2 worldwide citation)

A process for producing chlorosulfate and sulfamate esters of 2,3:4,5-bis-O-(1-methylethylidene)- beta -D-fructopyranose and (1-methylcyclohexyl)methanol is disclosed. The process involves a two step procedure involving in the first step reacting of an alcohol with sulfuryl chloride in the presence ...


5
Maryanoff Cynthia A: Process for the preparation of $i(n)-(4-hydroxyphenyl)-retinamide. Ortho Pharmaceutical Corporation, CIAMPORCERO Audley A Jr, February 2, 1995: WO/1995/003274 (1 worldwide citation)

This invention is directed to an efficient, mild, high yield process for the large scale synthesis of $i(N)-(4-hydroxyphenyl)-retinamide comprising the preferred steps of reacting retinoic acid with dimethylchloroformamidinium chloride to form retinoyl chloride which in turn is reacted with bis-($i( ...


6
Abdel Magid Ahmed F, Harris Bruce D, Maryanoff Cynthia A: Process for preparing derivatives of [(1,5-diaryl)pyrazol-3-yl]propanoic acid. Ortho Mcneil Pharm, April 28, 2004: EP1413575-A2

A process of preparing a compound of formula III wherein the substituents are defined in the specification. The compound of formula III can be used in the preparation of 1,5-diaryl-3-substituted pyrazoles.


7
Akerman Eugena A, Cleeren Dirk, Llanos Gerard, Maryanoff Cynthia A, Papandreou Georgios, Rion William L, Six Karel, Todd Thomas L: Method of coating stents. Cordis, March 8, 2006: EP1632254-A1

An improved process for coating implantable medical devices utilizes a number of techniques for improving the stability of therapeutic agents contained within the coating. In one embodiment, the process comprises: (a) applying a primer coating on the implantable medical devices, including the applic ...


8
Alquier Lori, Maryanoff Cynthia A, Veselov Vladmir: Data and application model for configurable tracking and reporting system. Cordis, February 18, 2009: EP2026222-A1

A software application, which allows the addition, modification and deletion of database fields dynamically, may be utilized without having to modify the database structure, application code, or user interface elements. Essentially, additional attributes may be added, subtracted or changed by users ...


9
Maryanoff Cynthia A, Raffa Robert B, Villani Frank J: Stock-mere de n-oxyde de tramadol, enantiomeres et compositions qui en derivent, et usage, A tramadol n-oxide material, enantiomers and compositions thereof, and their use. Mcneilab, Ortho Mcneil Pharmaceutical, OGILVY RENAULT SENCRLSRL, April 29, 2003: CA2078028

This invention relates to a tramadol N-oxide material,enantiomers and compositions thereof and their use. The tramadol N-oxide material and compositions thereof are pharmacologically usefulin treating pain, diarrhea and tussive conditions. The tramadol N-oxide is also subject to less side-effects as ...


10
Maryanoff Cynthia A, Scott Lorraine, Sorgi Kirk L: Procede pour la preparation de derives chlorosulfate et sulfamate du 2,3:4,5-bis-0-(1-methylethylidene)-beta-d-fructopyranose et du (1-methylcyclohexyl)methanol, Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-0-(1-methylethylidene)-beta-d-fructopyranose and (1-methylcyclohexyl)methanol. Mcneilab, Ortho Mcneil Pharmaceutical, OGILVY RENAULT SENCRLSRL, September 16, 2003: CA2078519

A process for producing chlorosulfate and sulfamate esters of2,3:4,5-bis-O-(1-methylethylidene)-.beta.-D-fructopyranose and(1-methylcyclohexyl)methanol is disclosed. The process involves a two stepprocedure involving in the first step reacting of an alcohol with sulfurylchloride in the presence of a ...