1
Charles R Cantor, Christof M Niemeyer, Cassandra L Smith, Takeshi Sano, Donald J Hnatowich, Mary Rusckowski: Self-assembling multimeric nucleic acid constructs. Trustees of Boston University, James Remenick, Baker & Botts L, October 1, 1996: US05561043 (45 worldwide citation)

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify d ...


2
Charles R Cantor, Christof M Niemeyer, Cassandra L Smith, Takeshi Sano, Donald J Hnatowich, Mary Rusckowski: Self-assembling multimeric nucleic acid constructs. Trustees of Boston University, Univ of Mass Medical Center, Medlen & Carroll, October 12, 1999: US05965133 (19 worldwide citation)

The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify d ...


3

4
Donald J Hnatowich, Mary Rusckowski, Guozheng Liu: Morpholino imaging and therapy. Immunomedics, Heller Ehrman White and McAuliffe, May 31, 2005: US06899864 (6 worldwide citation)

The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate containers, (a) a first conjugate comprising a targeting moiety and a Morpholino oligomer, wherein the tar ...


5
Young H Kim, Ducksoo Kim, Mary Rusckowski: Biomarkers of vulnerable atherosclerotic plaques and methods of use. University of Massachusetts, Mirick O Connell DeMallie & Lougee, Roger P Zimmerman, July 14, 2009: US07560227 (1 worldwide citation)

The present invention provides compositions suitable for use as biomarkers of vulnerable plaques as well as methods for the use of such compositions. In preferred embodiments, specific molecular imaging agents are provided that permit the selective identification of vulnerable plaques in coronary an ...


6
Brian D Gray, Mary Rusckowski, Koon Y Pak: Molecular probes for multimodality imaging and tracking of stem cells. University of Massachusetts, Milstein Zhang & Wu, November 15, 2016: US09492571

The invention relates to novel multi-modality probes for imaging, tracking and analyzing stem cells and related biological samples, and methods of preparation and use thereof. The molecular probes of the invention are constructed, for example, by utilizing (a) the high selectivity of long hydrocarbo ...


7
Young H Kim, Ducksoo Kim, Mary Rusckowski: Biomarkers of vulnerable atherosclerotic plaques and methods of use. University of Massachusetts, Mirick O Connell Demallie & Lougee, September 6, 2007: US20070207507-A1

The present invention provides compositions suitable for use as biomarkers of vulnerable plaques as well as methods for the use of such compositions. In preferred embodiments, specific molecular imaging agents are provided that permit the selective identification of vulnerable plaques in coronary an ...


8
Donald J Hnatowich, Mary Rusckowski, Guozheng Liu: Morpholino imaging and therapy. University of Massachusetts, Stephen B Maebius, Foley & Lardner Washington Harbour, January 2, 2003: US20030003102-A1

The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate containers, (a) a first conjugate comprising a targeting moiety and a Morpholino oligomer, wherein the tar ...


9
Donald J Hnatowich, Mary Rusckowski: Bacteriophage imaging of inflammation. Fish & Richardson PC, November 17, 2005: US20050255043-A1

Labeled bacteriophage are disclosed which are useful for detecting a bacterial infection in vivo.


10
Don Hnatowich, Kayoko Nakamura, Yi Wang, Xinrong Liu, Jiang He, Surong Zhang, Mary Rusckowski: Antisense and pretargeting optical imaging. University of Massachusetts, June 30, 2011: US20110158913-A1

The present invention relates, in part, to detectably labeled oligomer duplexes and their use in optical imaging, including, in vivo optical imaging. The invention includes methods of optical imaging including in vivo pretargeting methods and in vivo antisense optical imaging methods.