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Mary E Abreu, Waclaw Rzeszotarski, Donald J Kyle, Roger N Hiner, Richard L Elliott: Corticotropin-releasing factor antagonism compounds. Nova Pharmaceutical Corporation, Vincent L Fabiano, November 5, 1991: US05063245 (63 worldwide citation)

The present invention relates to a method of producing corticotropin-releasing factor (CRF) antagonist activity and thus provides a method of treating a wide range of stress-related disorders, including affective illnesses, such as depression and anxiety, as well as irritable bowel syndrome, anorexi ...


2
Richard E Mewshaw, Carl Kaiser, Mary E Abreu: 5,6,7,8,9,10-hexahydro-7 ,10-iminocyclohept[b]indole,-6,7,8,9,10-hexahydro-7,11-imino-5H-cyclooct[ b]indole and substituted derivatives. Scios Nova, Vanessa L Appleby, Vincent Fabiano, Pete Shearer, October 5, 1993: US05250537 (17 worldwide citation)

5,6,7,8,9,10-Hexahydro-7,10-iminocyclohept[b]indole, 6,7,8,9,10,11-hexahydro-7,11-imino-5H-cyclooct[b]indole and substituted derivatives are effective in the treatment of psychoses with limited liability to produce concomitant adverse extrapyramidal symptoms. These compounds are also useful for trea ...