1
Marvin H Caruthers, Mark D Matteucci: Process for preparing polynucleotides. University Patents, George M Yahwak, July 3, 1984: US04458066 (892 worldwide citation)

New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).


2
Marvin H Caruthers, Serge L Beaucage: Phosphoramidite compounds and processes. University Patents, Scully Scott Murphy & Presser, November 15, 1983: US04415732 (424 worldwide citation)

A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.


3
Marvin H Caruthers, Mark D Matteucci: Nucleosides useful in the preparation of polynucleotides. University Patents, George M Yahwak, February 19, 1985: US04500707 (362 worldwide citation)

New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).


4
Marvin H Caruthers, William S Marshall, Wolfgang Brill, John Nielsen: Polynucleotide phosphorodithioate. University Patents, Yahwak & Associates, September 26, 1995: US05453496 (287 worldwide citation)

Oligonucleotides having at least one phosphorodithioate internucleotide linkage. Phosphorodithioate oligonucleotides exhibit stronger antiviral activity than the corresponding phoshorothioate derivatives.


5
Marvin H Caruthers, William S Marshall: Polynucleotide phosphorodithioates. University Patents, Yahwak & Associates, January 11, 1994: US05278302 (269 worldwide citation)

The present invention relates to novel oligonucleotides having phosphorodithioate internucleotide linkages which may be used for the treatment of diseases caused by viruses.


6
Marvin H Caruthers, Serge L Beaucage: Process for oligonucleo tide synthesis using phosphormidite intermediates. University Patents, Yahwak & Associates, November 27, 1990: US04973679 (253 worldwide citation)

A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.


7
Marvin H Caruthers, Serge L Beaucage: Phosphoramidite nucleoside compounds. University Patents, George M Yahwak, May 26, 1987: US04668777 (236 worldwide citation)

A new class of nucleoside phosphoramidites which are relatively stable to permit isolation thereof and storage at room temperature. The phosphoramidites are derivatives of saturated secondary amines.


8

9
Marvin H Caruthers, Mark D Matteucci: Process for preparing polynucleotides. University Patents, Yahwak & Associates, October 6, 1992: US05153319 (121 worldwide citation)

New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic (DNA) acids, ar ...


10
Stephen Scaringe, Marvin H Caruthers: Orthoester protecting groups in RNA synthesis. The Regents of The University of Colorado, March 30, 1999: US05889136 (81 worldwide citation)

Phosphoramidite oligonucleotide synthesis is facilitated by the use of fluoride-labile 5' silyl protecting groups. RNA synthesis is improved by the use of 2' orthoester protecting groups. Reactions are conducted on a solid phase support, and acidic deprotection conditions are avoided, as is the nece ...