1
William N Drohan, Martin J MacPhee, Shirley I Miekka, Manish S Singh, Clive Elson, John R Taylor Jr: Chitin hydrogels, methods of their production and use. Chitogenics, The American National Red Cross, Coalition for Hemophilia B, Lahive & Cockfield, September 26, 2000: US06124273 (165 worldwide citation)

This invention is directed to the preparation and utilization of supplemented chitin hydrogels, such as chitosan hydrogels. Further provided are biomaterials comprising same. The particular supplement delivered by the chitin hydrogel is selected as a function of its intended use. In one embodiment, ...


2
Shirley I Miekka, Wilson Burgess, William N Drohan, Yuri Griko, Martin J MacPhee, David M Mann: Methods for sterilizing biological materials. Clearant, Morgan Lewis & Bockius, September 20, 2005: US06946098 (120 worldwide citation)

Methods are disclosed for sterilizing biological materials to reduce the level therein of one or more biological contaminants or pathogens, such as prions, responsible for the disease states known as transmissible spongiform encephalopathies (TSEs) in mammals. These methods involve sterilizing biolo ...


3
Willson H Burgess, Howard P Greisler, William N Drohan, Thomas Maciag, Martin J MacPhee: Method of preparing a tissue sealant-treated biomedical material. Loyola University of Chicago, The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, May 6, 2003: US06559119 (84 worldwide citation)

This invention provides methods for the preparation of a tissue sealant-treated biomaterial, wherein the tissue sealant used in the method comprises at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflammatory compounds, antimicrobial composit ...


4
Martin J MacPhee, William H Drohan, Dawson Beall, Stanley A Friedman, David Tuthill, Valdislav Bayer: Hemostatic sandwich bandage. The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, July 13, 2004: US06762336 (59 worldwide citation)

The present invention relates to a haemostatic multilayer bandage that comprises preferably a thrombin layer between two fibrinogen layers. The dressing may contain other resorbable materials such as glycolic acid or lactic acid based polymers or copolymers. The inventive haemostatic bandage is usef ...


5
William N Drohan, Martin J MacPhee, Hernan Nunez, Gene Liau, Thomas Maciag, Wilson H Burgess: Methods for treating wound tissue and forming a supplemented fibrin matrix. The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, March 27, 2007: US07196054 (37 worldwide citation)

This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antimicrobial composition. The composition may be further supplemented with, for example, one or more antibodi ...


6
William N Drohan, Martin J MacPhee, Wilson H Burgess, Hernan Nunez, Manish Singh, Gene Liau, Thomas Maciag: Supplemented and unsupplemented tissue sealants, methods of their production and use. The American National Red Cross, Stern Kessler Goldstein & Fox P L L C, March 13, 2007: US07189410 (33 worldwide citation)

This invention provides a fibrin sealant bandage, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, anti-inflammatory compou ...


7
William N Drohan, Martin J MacPhee, Hernan Nunez, Gene Liau, Wilson H Burgess, Thomas Maciag: Supplemented fibrin matrix delivery systems. The American National Red Cross, Sterne Kessler Goldstein & Fox P L L C, June 12, 2007: US07229959 (27 worldwide citation)

This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one antibody. The composition may be further supplemented with, for example, one or more analgesics, antimicrobial ...


8
Shirley I Miekka, William N Drohan, Thomas R Jameson, Manish P Singh, John R Taylor Jr, Martin J MacPhee: Methods of production and use of liquid formulations of plasma proteins. The American National Red Cross, The Coalition for Hemophilia B, Sterne Kessler Goldstein & Fox P L L C, July 20, 1999: US05925738 (27 worldwide citation)

The present invention relates to the preparation and use of liquid formulations of plasma proteins, particularly blood coagulation factors. More specifically, the present invention relates to stable liquid formulations of Factor VIII and Factor IX that can be administered by injection or infusion to ...


9
David M Mann, Wilson Burgess, William N Drohan, Yuri Griko, Martin J Macphee: Methods for sterilizing preparations of digestive enzymes. Clearant, Fleshner & Kim, June 15, 2004: US06749851 (8 worldwide citation)

Methods are disclosed for sterilizing preparations of digestive enzymes to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsi ...


10
Teri Grieb, Wilson H Burgess, William N Drohan, Ren Yo Forng, Martin J MacPhee, David M Mann, Anna McBain: Methods for sterilizing preparations of monoclonal immunoglobulins. Clearant, Fleshner & Kim, February 24, 2004: US06696060 (5 worldwide citation)

Methods are disclosed for sterilizing preparation of monoclonal immunoglobulins to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas, prions and parasites.