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Thomas H Shaffer, Marla R Wolfson, Thomas F Miller, Raymond Foust III: Breathable liquid elimination analysis. Temple University Of The Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco P C, January 7, 1997: US05590651 (254 worldwide citation)

The amount of breathable liquid eliminated from a mammal through volatilization in the lungs and/or through skin transpiration is detected by measuring the amount of saturation of the expiratory gas by vapors or the breathable liquid. Instantaneous saturation values are employed to gauge the amount ...


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Robert G Stern, Thomas H Shaffer, Marla R Wolfson: Fluorochemical liquid augmented cryosurgery. Temple University of the Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco PC, April 21, 1998: US05741248 (201 worldwide citation)

A method for cryogenic treatment of a lesion which includes the steps of delivering a fluorochemical liquid to the lesion, placing at least one cryoprobe into the lesion, and circulating cryogenic fluid through the cryoprobe, the cryogenic fluid causing an ice ball to form in a vicinity around the c ...


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K Michael Sekins, Thomas H Shaffer, Marla R Wolfson: Pulmonary delivery of therapeutic agent. Alliance Pharmaceutical, Knobbe Martens Olson & Bear, January 13, 1998: US05707352 (198 worldwide citation)

An apparatus for producing a uniformly dispersed drug-containing phase within a continuous liquid delivery phase.


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K Michael Sekins, Thomas H Shaffer, Marla R Wolfson: Lung cancer hyperthermia via ultrasound and/or convection with perfiuorochemical liquids. Biopulmonics, Temple University Of the Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco, October 27, 1992: US05158536 (161 worldwide citation)

A hyperthermic treatment of lung cancer, by temporarily filling with a liquid medium preselected pulmonary air passages adjoining pulmonary tissues containing malignant cells, circulating exogenously heated liquid medium at from about 41.degree. to ab


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Thomas H Shaffer, Marla R Wolfson: Process control and apparatus for ventilation procedures with helium and oxygen mixtures. Temple University Of The Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco, July 4, 1995: US05429123 (90 worldwide citation)

A process is provided for controlling a ventilation procedure wherein a heliox ventilation system passes a breathing medium through at least a portion of a patient's pulmonary pathways. In this process, desired ranges for certain process parameters associated with the heliox ventilation system are e ...


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Thomas H Shaffer, Marla R Wolfson: Process control for liquid ventilation and related procedures. Temple University Of The Commonwealth System of Higher Education, Seidel Gonda Lavorgna & Monaco, August 9, 1994: US05335650 (36 worldwide citation)

A process is provided for controlling a ventilation procedure wherein a liquid ventilation system passes a breathing liquid through at least a portion of a patient's pulmonary pathways. In this process, desired ranges for certain process parameters associated with the liquid ventilation system are e ...


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K Michael Sekins, Thomas H Shaffer, Marla R Wolfson: Methods for the pulmonary delivery of biological agents. Alliance Pharmaceutical, Knobbe Martens Olson & Bear, June 5, 2001: US06242472 (34 worldwide citation)

Methods of delivering a therapeutic or diagnostic agent in a perfluorochemical liquid carrier are provided. In preferred embodiments, the disclosed methods use compositions in the form of an emulsion or a dispersion for delivery of a biological agent to the pulmonary air passages.


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K Michael Sekins, Thomas H Shaffer, Marla R Wolfson: Fluorocarbon compositions for pulmonary therapy. Alliance Pharmaceutical, Knobbe Martens Olson & Bear, December 26, 2000: US06166092 (18 worldwide citation)

Biocompatible fluorocarbon compositions are provided which may be used for the delivery of bioactive agents to the pulmonary air passages of a patient. Preferred compositions comprise a fluorocarbon liquid carrier having a bioactive agent in a solid or immiscible liquid form distributed therein. The ...


10
Thomas H Shaffer, Marla R Wolfson, James L Heckman, John Hoffman: Liquid ventilator. Alliance Pharmaceutical, Temple University of the Commonwealth System of Higher Education, Knobbe Martens Olson & Bear, August 22, 2000: US06105572 (8 worldwide citation)

A liquid ventilator having a dual loop, single pump configuration is disclosed. The liquid ventilator preferably utilizes two three-way valves for routing liquid from a reservoir in a regeneration apparatus and to a patient's pulmonary system, and back to the reservoir again. A controller controls t ...



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