1
Axel F Brisken, John R McKenzie, Robert F Zuk, Menahem Nassi, Mark W Cowan, Paul D Corl: Therapeutic ultrasonic catheter for delivering a uniform energy dose. Pharmasonics, Townsend and Townsend and Crew, October 2, 2001: US06296619 (345 worldwide citation)

A method of treating a target region in a body lumen, said method comprising: directing a uniform dose of ultrasonic energy from an interior of the lumen radially outward over a treatment length of the lumen, wherein the dosage of ultrasonic energy received at any one point along the length varies b ...


2
N Parker Willis, Axel F Brisken, Mark W Cowan, Michael Pare, Robert Fowler, James Brennan: Optimizing energy transmission in a leadless tissue stimulation system. EBR Systems, Wilson Sonsini Goodrich & Rosati, May 6, 2014: US08718773 (173 worldwide citation)

Method and systems for optimizing acoustic energy transmission in implantable devices are disclosed. Transducer elements transmit acoustic locator signals towards a receiver assembly, and the receiver responds with a location signal. The location signal can reveal information related to the location ...


3
Mark W Cowan, Debra S Echt, Richard E Riley, Axel F Brisken: Leadless tissue stimulation systems and methods. EBR Systems, Townsend and Townsend and Crew, October 27, 2009: US07610092 (115 worldwide citation)

Systems including an implantable receiver-stimulator and an implantable controller-transmitter are used for leadless electrical stimulation of body tissues. Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an external or implantable controll ...


4
Axel F Brisken, Robert Zuk, John R McKenzie, Mark W Cowan: Methods and apparatus for uniform transcutaneous therapeutic ultrasound. Pharmasonics, Townsend and Townsend and Crew, June 10, 2003: US06575956 (114 worldwide citation)

A wide beam ultrasound delivery system providing a uniform exposure field is used to enhance the uptake of injected substances and/or to enhance the transfection of DNA in the tissues of human subject, or reduce the amount of vascular intimal hyperplasia in human subjects following vascular injury.


5
Mark W Cowan, Debra S Echt, Richard E Riley, Axel F Brisken: Leadless tissue stimulation systems and methods. EBR Systems, Townsend and Townsend and Crew, July 7, 2009: US07558631 (97 worldwide citation)

Systems including an implantable receiver-stimulator and an external controller-transmitter system are used for leadless acute stimulation of the heart, particularly after heart surgery. Cardiac pacing and arrhythmia control is accomplished with one or more implantable receiver-stimulators and an ex ...


6
Menahem Nassi, Paul D Corl, Ronald G Williams, Mark W Cowan, Jerome Segal: Apparatus and method for continuously measuring volumetric blood flow using multiple transducer and catheter for use therewith. Cardiometrics, Flehr Hohbach Test Albritton & Herbert, August 14, 1990: US04947852 (97 worldwide citation)

Apparatus for measuring volumetric flow of a liquid in a vessel having a wall and having an axis extending longitudinally of the vessel parallel to the vessel wall. A flexible catheter is adapted to be disposed in the vessel. First and second ultrasonic transducers are carried by the catheter on one ...


7
Axel F Brisken, Mark W Cowan, Debra S Echt, Richard E Riley: Implantable transducer devices. EBR Systems, Townsend and Townsend and Crew, October 20, 2009: US07606621 (91 worldwide citation)

Receiver-stimulators comprise a nearly isotropic transducer assembly, demodulator circuitry, and at least two tissue contacting electrodes. Use of near isotropic transducers allows the devices to be implanted with less concern regarding the orientation relative to an acoustic energy source. Transduc ...


8
Mark W Cowan, Richard E Riley, Axel F Brisken, Debra S Echt: Systems and methods for implantable leadless nerve stimulation. EBR Systems, Kilpatrick Townsend & Stockton, February 22, 2011: US07894907 (91 worldwide citation)

Systems and methods are disclosed to stimulate nerves to treat medical conditions such as pain, and other conditions, such as, CHF, obesity, incontinence, etc., that could be controlled by the stimulation of the vagal nerves. The invention uses electrical stimulation of the nerve, where vibrational ...


9
Mark W Cowan, Richard E Riley, Axel F Brisken, Debra S Echt: Systems and methods for implantable leadless spine stimulation. EBR Systems, Kilpatrick Townsend & Stockton, March 1, 2011: US07899542 (65 worldwide citation)

Systems and methods are disclosed to stimulate spine tissue to treat medical conditions such as pain and spinal injury. The invention uses electrical stimulation of the spine, where vibrational energy from a source is received by an implanted device and converted to electrical energy and the convert ...


10
Debra S Echt, Axel F Brisken, Richard E Riley, Mark W Cowan: Vibrational therapy device used for resynchronization pacing in a treatment for heart failure. EBR Systems, Townsend and Townsend and Crew, May 23, 2006: US07050849 (54 worldwide citation)

Systems for pacing the heart include a vibrational transducer which directs energy at the heart, usually at at least a ventricle, to pace the heart and to promote synchronized contraction of the ventricles. Optionally, additional vibrational and/or electrical stimulation may be provided. The vibrati ...