1
Mark S Humayun, Eugene de Juan Jr, Robert J Greenberg: Visual prosthesis and method of using same. John Hopkins University School of Medicine, Leydig Voit & Mayer, August 10, 1999: US05935155 (464 worldwide citation)

A visual prosthesis comprises a camera for perceiving a visual image and generating a visual signal output, retinal tissue stimulation circuitry adapted to be operatively attached to the user's retina, and wireless communication circuitry for transmitting the visual signal output to the retinal tiss ...


2
Eugene de Juan Jr, Mark S Humayun, D Howard Phillips: Retinal microstimulation. Duke University, Bell Seltzer Park & Gibson P A, May 5, 1992: US05109844 (400 worldwide citation)

A method for stimulating a retinal ganglion cell in a retina without penetrating the retinal basement membrane at the surface of the retina comprises: (a) positioning a ganglion cell stimulating electrode on or above the retinal basement membrane; (b) providing a ground electrode in operative associ ...


3
Robert J Greenberg, Mark S Humayun, Eugene de Juan Jr: Method for preferential outer retinal stimulation. Johns Hopkins University, Leydig Voit & Mayer, August 31, 1999: US05944747 (113 worldwide citation)

A method of focused phosphene generation through deeper intermediate retinal cellular electrical stimulation to the exclusion of direct ganglion cellular electrical stimulation comprises the steps of: a) positioning a stimulating electrode in the vicinity of retinal tissue; and b) applying a long du ...


4
Ellis Meng, Yu Chong Tai, Mark S Humayun, Rajat Agrawal, Ronalee Lo, Jason Shih, Kenrick Kuwahara, Po Ying Li, Damien Rodger, Po Jui Chen: MEMS device and method for delivery of therapeutic agents. The University of Southern California, Goodwin Procter, February 15, 2011: US07887508 (40 worldwide citation)

Embodiments of an implantable device for delivering a therapeutic agent to a patient includes a reservoir configured to contain a liquid comprising the therapeutic agent and a cannula in fluid communication with the reservoir. The device and related methods may provide such features as constant-flow ...


5
Peter Krulevitch, Dennis L Polla, Mariam N Maghribi, Julie Hamilton, Mark S Humayun, James D Weiland: System of fabricating a flexible electrode array. Lawrence Livermore National Security, Eddie E Scott, John H Lee, October 12, 2010: US07810233 (32 worldwide citation)

An image is captured or otherwise converted into a signal in an artificial vision system. The signal is transmitted to the retina utilizing an implant. The implant consists of a polymer substrate made of a compliant material such as poly(dimethylsiloxane) or PDMS. The polymer substrate is conformabl ...


6
Mark S Humayun, Patrick S Jensen, Terry H Shelley, Gildo Y Fujii, Hany S Hamza, Aaron C Barnes, Eugene deJuan Jr: Device and method for manual retinal vein catheterization. The Johns Hopkins University, Edwards Angell Palmer & Dodge, Peter F Corless, Lisa Swiszcz Hazzard, May 15, 2007: US07217263 (32 worldwide citation)

A microcatheter system that allows for vascular infusion into retinal veins for extended periods of time. The microcatheter system includes a flexible cannula that is inserted into the retinal vein lumen and that remains stably within the retinal vein lumen without being held by a robot, micromanipu ...


7
Patrick J Nasiatka, Michelle C Hauer, Noelle R B Stiles, Armand R Tanguay Jr, Mark S Humayun: Intraocular camera for retinal prostheses. University of Southern California, McDermott Will & Emery, June 12, 2012: US08197539 (31 worldwide citation)

An intraocular camera for retinal prostheses may include an optical imaging system comprising a set of optical elements for forming an image of the external world on an image sensor array, wherein the optical elements and the image sensor array may be enclosed in an implantable biocompatible housing ...


8
Arup Roy, Robert J Greenberg, Mark S Humayun, Kelly H McClure: Neural stimulation for increased persistence. Second Sight Medical Products, Scott B Dunbar, Alessandro Steinfl, August 4, 2009: US07571004 (30 worldwide citation)

The present invention is a method of improving the persistence of electrical neural stimulation, and specifically a method of improving the persistence of an image supplied to a retina, or visual cortex, through a visual prosthesis. A continuously stimulated retina, or other neural tissue, will dese ...


9
Robert J Greenberg, Da Yu Chang, Rajat Agrawal, Brian V Mech, Mark S Humayun, James Singleton Little, Kevin Wilkin: Retinal prosthesis with side mounted inductive coil. Second Sight Medical Products, Scott B Dunbar, Tomas Lendvai, June 5, 2007: US07228181 (29 worldwide citation)

The invention is a retinal prosthesis with an inductive coil mounted to the side of the eye by means of a strap around the eye. This allows for close coupling to an external coil and movement of the entire implanted portion with movement of the eye ball.


10
Yu Chong Tai, Po Jui Chen, Damien C Rodger, Mark S Humayun: Microfluidic valve having free-floating member and method of fabrication. California Institute of Technology, Vista IP Law Group, October 13, 2009: US07600533 (26 worldwide citation)

Micro check valves having a free-floating member for controlling flow of fluid in microfluidic and biomedical applications and methods of fabrication. A micro check valve includes a valve seat, a valve cap that contacts the valve seat and an untethered floating member that can move between the valve ...