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Diane Harris Boschelli, Annette Marian Doherty, Ali Fattaey, David William Fry, Susanne Andrea Trumpp Kallmeyer, Zhipei Wu, Ellen Myra Dobrusin, Mark Robert Barvian: Pyrido[2,3-D]pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation. Warner Lambert Company, Charles W Ashbrook, Rosanne Goodman, December 24, 2002: US06498163 (43 worldwide citation)

This invention provides pyridopyrimidines and 4-aminopyrimidines that are useful for treating cell proliferative disorders, such as cancer and restenosis. We have now discovered a group of 7,8-dihydro-2-(amino and thio)pyrido[2,3-d]pyrimidines and 2,4-diaminopyrimidines that are potent inh ...


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Mark Robert Barvian, William Alexander Denny, Ellen Myra Dobrusin, James Marino Hamby, Howard Daniel Hollis Showalter, Andrew Mark Thompson, Roy Thomas Winters, Zhipei Wu: Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation. Warner Lambert Company, Charles W Ashbrook, November 21, 2000: US06150359 (4 worldwide citation)

This invention relates to the inhibition of protein tyrosine kinase (PTK) and cell cycle kinase mediated cellular proliferation. More specifically, this invention relates to naphthyridinones and their use in inhibiting cellular proliferation and PTK or cell cycle kinase enzymatic activity.


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Mark Robert Barvian, Ellen Myra Dobrusin, James Stanley Kaltenbronn, Peter L Toogood, Roy Thomas Winters, Inderjit S Sidhu, Rajeshwar Singh, Yadagiri Bathini, Ronald George Micetich: Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes. Warner Lambert Company, Bryan C Zielinski, Wendy L Hsu, January 3, 2006: US06982260 (2 worldwide citation)

This invention provides quinazolines that are useful for treating cell proliferative diseases and disorders, such as cardiovascular diseases, infections, cancers, autoimmune diseases, gout, kidney disease, and neurodegenerative diseases and disorders such as Alzheimer's disease. We have now discover ...


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Corinne Elizabeth Augelli Szafran, Mark Robert Barvian, Christopher Franklin Bigge, Shelly Ann Glase, Shunichiro Hachiya, John Steven Kiely, Takenori Kimura, Yingjie Lai, Annette Theresa Sakkab, Mark James Suto, Larry Craswell Walker, Tomoyuki Yasunaga, Nian Zhuang: Method of inhibiting amyloid protein aggregation and imaging amyloid deposits. Pfizer, Peter C Richardson, Lorraine B Ling, James A Jubinsky, December 6, 2005: US06972287 (2 worldwide citation)

The present invention provides a method of treating Alzheimer's disease using a compound of Formula (I). Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of the Formula (I) and a method of imaging amyloid deposits, as well as new compounds of Formula (I).


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Corinne Elizabeth Augelli Szafran, Mark Robert Barvian, Christopher Franklin Bigge, Shelly Ann Glase, Shunichiro Hachiya, John Steven Kiely, Takenori Kimura, Yingjie Lai, Annette Theresa Sakkab, Mark James Suto, Lary Craswell Walker, Tomoyuki Yasunaga, Nian Zhuang: Method of inhibiting amyloid protein aggregation and imaging amyloid deposits. Scully Scott Murphy & Presser PC, November 4, 2004: US20040220235-A1

The present invention provides a method of treating Alzheimer's disease using a compound of Formula I 1 Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula I and a method of imaging amyloid deposits, as well as new compounds of Formula I.


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