1
Mark G Allen, Mark R Prausnitz, Devin V McAllister, Florent Paul Marcel Cros: Microneedle devices and methods of manufacture and use thereof. Georgia Tech Research Corporation, Sutherland Asbill & Brennan, January 1, 2002: US06334856 (605 worldwide citation)

Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can in ...


2
Mark R Prausnitz, Mark G Allen, Sebastien Henry, Devin V McAllister, Donald E Ackley, Thomas Jackson: Devices and methods for enhanced microneedle penetration of biological barriers. Georgia Tech Research Corporation, Ropes & Gray, June 1, 2004: US06743211 (577 worldwide citation)

Microneedle devices and methods of use thereof are provided for the enhanced transport of molecules, including drugs and biological molecules, across tissue by improving the interaction of microneedles and a deformable, elastic biological barrier, such as human skin. The devices and methods act to ( ...


3
Mark R Prausnitz, Mark G Allen, Devin V McAllister, Sebastien Henry: Microneedle device for transport of molecules across tissue. Georgia Tech Research Corporation, Ropes & Gray, January 7, 2003: US06503231 (369 worldwide citation)

Microneedle devices for transport of therapeutic and diagnostic materials and/or energy across tissue barriers, and methods for manufacturing the devices, are provided. The microneedles are hollow and/or porous and have diameters between about 10 nm and 1 mm. The microneedle devices permit drug deli ...


4
Mark R Prausnitz, Mark G Allen, Inder Jeet Gujral: Microneedle device for extraction and sensing of bodily fluids. Georgia Tech Research Corporation, Ropes and Gray, March 18, 2008: US07344499 (304 worldwide citation)

Microneedle devices are provided for controlled sampling of biological fluids in a minimally-invasive, painless, and convenient manner. The microneedle devices permit in vivo sensing or withdrawal of biological fluids from the body, particularly from or through the skin or other tissue barriers, wit ...


5
Mark R Prausnitz, Mark G Allen, Inder Jeet Gujral: Microneedle drug delivery device. Georgia Tech Research Corporation, Ropes & Gray, August 26, 2003: US06611707 (200 worldwide citation)

Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which ...


6
Mark R Prausnitz, Mark G Allen, Inder Jeet Gujral: Microneedle drug delivery device. Georgia Tech Research Corporation, Fish & Neave IP Group Ropes & Gray, June 5, 2007: US07226439 (123 worldwide citation)

Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which ...


7
James C Weaver, Tani Chen, Christopher Cullander, Richard Guy, Robert S Langer, Thomas E Zewert, Uwe Pliquett, Rita Vanbever, Mark R Prausnitz: Introduction of modifying agents into skin by electroporation. Massachusetts Institute of Technology, The Regents of the University of California, Hamilton Brook Smith & Reynolds P C, June 15, 1999: US05911223 (93 worldwide citation)

A method of modifying epidermis for transport of a material by electroporation includes applying to epidermis an agent that, upon entry into the epidermis, will modify the epidermis to thereby cause and altered rate of transport of a material across the epidermis. Typically, the altered rate will be ...


8
Uwe Pliquett, Mark R Prausnitz, James C Weaver, Robert S Langer: Method for rapid temporal control of molecular transport across tissue. Massachusettes Institute of Technology, Hamilton Brook Smith & Reynolds P C, August 20, 1996: US05547467 (58 worldwide citation)

A method is disclosed for treating tissue in response to a stimulus generated by the tissue. In one embodiment, the method transdermally treats an organism in response to a stimulus. In this embodiment, the medication is applied to epidermis of the organism, and the epidermis is electroporated in re ...


9
Uwe Pliquett, Mark R Prausnitz, James C Weaver, Robert S Langer: Method for rapid temporal control of molecular transport across tissue. Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds P C, September 16, 1997: US05667491 (44 worldwide citation)

A method is disclosed for treating tissue in response to a stimulus generated by the tissue. In one embodiment, the method transdermally treats an organism in response to a stimulus. In this embodiment, the medication is applied to epidermis of the organism, and the epidermis is electroporated in re ...


10
Carolyn S Murphy, Mark R Prausnitz: Silicone hairspray compositions. The Procter & Gamble Company, Gretchen R Hatfield, Steven J Goldstein, January 8, 1991: US04983377 (36 worldwide citation)

Silicone hairspray compositions which give hair volume and hold but with a soft feel are disclosed. These compositions comprise from about 0.05% to about 10.0% of a nonrigid silicone gum, said gum having dispersed therein from about 0.03% to about 8.0% of unsolubilized particulate matter which is pr ...