1
Mark K Malmros: Analytical device having semiconductive organic polymeric element associated with analyte-binding substance. Omri M Behr, April 24, 1984: US04444892 (239 worldwide citation)

A method, sensor and semiconductor device for determining the concentration of an analyte in a medium. The device features an element constructed of semiconductive organic polymer associated with a binding substance having specific affinity for the analyte.


2
Richard C Hevey, Mark K Malmros: Methods for the detection and determination of ligands. Calbiochem Behring, Natalie Jensen, October 14, 1980: US04228237 (117 worldwide citation)

A method for determining the presence of a ligand in a liquid medium which utilizes enzyme labeled avidin and biotin labeled reagent in a specific binding process wherein the ligand to be detected is contacted with an insoluble phase containing specific binding substance for the ligand. Various prot ...


3
Mark K Malmros: Analytical device having semiconductive polyacetylene element associated with analyte-binding substance. June 15, 1982: US04334880 (33 worldwide citation)

A method, sensor and semiconductor device for determining the concentration of an analyte in a medium. The device features an element constructed of polyacetylene associated with a binding substance having specific affinity for the analyte.


4
Mark K Malmros, Julian Gulbinski III: Differential homogeneous immunosensor device. Ohmicron Corporation, Omri M Behr, April 10, 1990: US04916075 (20 worldwide citation)

There is provided a novel method of testing for the presence of an analyte in a fluid suspected of containing the same. In this method, in the presence of the analyte, a substance capable of modifying certain characteristics of the substrate is bound to the substrate and the change in these qualitie ...


5
Mark K Malmros, Julian Gulbinski III, William S Collins, William Gibbs: Pyroelectric thermometric device. Ohmicron Corporation, Omri M Behr, April 28, 1992: US05108576 (17 worldwide citation)

A device for detecting the presence of a predetermined reactant in a fluid suspected of containing the same which comprises a pyroelectric film having a first and a second surface, a first electrode in contact with a portion of the first surface of said pyroelectric film, a second electrode in conta ...


6
Mark K Malmros, Raymond J Tucci, Pier J Cipriani: Biological stain composition, method of preparation and method of use for delineation of epithelial cancer. CTM Associates, William H Drummond, December 13, 1994: US05372801 (12 worldwide citation)

A biological stain composition contains toluidine blue O and a pharmaceutically acceptable oxidizing agent to convert any leuco toluidine blue O to the chromo form. A dry composition for preparing the stain includes the toluidine blue O, the oxidizing agent and an effervescent agent. These compositi ...


7
Richard C Hevey, Mark K Malmros, Wayne W Petko: Method for terminating a peroxidase catalyzed reaction. Calbiochem Behring, Natalie Jensen, November 18, 1980: US04234680 (9 worldwide citation)

Addition of a low concentration of an alkali metal metabisulfite completely stops color development in a peroxidase-labeled immunoassay wherein the peroxidase catalyzed reaction comprises oxidation of an achromatic substrate to the corresponding chromatic product in the presence of a peroxide.


8
Mark K Malmros, William S Collins, Pier J Cipriani, Dennis M Loreman: Bio-spectral imaging system and methods for diagnosing cell disease state. Henry N Wixon, Hale and Dorr, February 6, 2003: US20030026762-A1

A bio-spectral imaging system and methods for in situ diagnosis of a disease state in biological tissue or cells of a living organism are provided. In one form, a method includes applying to the tissue or cells in situ a biological stain composition that includes at least one metachromatic dye; perf ...


9
Mark K Malmros, William S Collins, Pier J Cipriani: Method of in situ diagnosis by spectroscopic analysis of biological stain compositions. Hale & Dorr, May 16, 2002: US20020058028-A1

A method is disclosed where one or more biological stains are applied to living tissue displaying, or suspected of having cells, or parts of the tissue which are diseased, metaplasic, or otherwise abnormal, including but not limited to lesions which may be thought pre-cancerous or cancerous. The sta ...