Signe Erickson Varner, Eugene DeJuan Jr, Terry Shelley, Aaron Christopher Barnes, Mark Humayun: Devices for intraocular drug delivery. The Johns Hopkins University, Peter F Corless, Edwards & Angell, April 13, 2004: US06719750 (218 worldwide citation)

An therapeutic agent delivery device that can allows is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred devices of the invention are minimally invasive, refillable and may be easily fixed to the tr ...

Wolfgang Fink, Eui Hyeok Yang, Yoshi Hishinuma, Choonsup Lee, Thomas George, Yu Chong Tai, Ellis Meng, Mark Humayun: Optically powered and optically data-transmitting wireless intraocular pressure sensor device. California Institute of Technology, Doheny Eye Institute, Fish & Neave IP Group, November 7, 2006: US07131945 (118 worldwide citation)

An implantable intraocular pressure sensor device for detecting excessive intraocular pressure above a predetermined threshold pressure is disclosed. The device includes a pressure switch that is sized and configured to be placed in an eye, wherein said pressure switch is activated when the intraocu ...

Yu Chong Tai, Ellis Meng, Po Jui Chen, Damien C Rodger, Mark Humayun: Implantable mechanical pressure sensor and method of manufacturing the same. California Institute of Technology, Christie Parker & Hale, August 7, 2007: US07252006 (53 worldwide citation)

A biocompatible, mechanical, micromachined pressure sensor and methods of manufacturing such a pressure sensor are provided. The pressure sensor of the current invention includes a high-aspect-ratio curved-tube structure fabricated through a one-layer parylene process. The pressure sensor of the cur ...

Changlin Pang, Fukang Jiang, Jason Shih, Sean Caffey, Mark Humayun, Yu Chong Tai: Drug-delivery pumps and methods of manufacture. MiniPumps, Bingham McCutchen, September 10, 2013: US08529538 (40 worldwide citation)

Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, a ...

Jerry Ok, Robert J Greenberg, Mark Humayun: Visual prosthesis including enhanced receiving and stimulating portion. Second Sight Medical Products, Thomas Lendval, Scott B Dunbar, September 5, 2006: US07103416 (38 worldwide citation)

A visual prosthesis including an enhanced receiving and stimulating portion for electrically stimulating retinal tissue to present an apparent image to a user. The prosthesis includes an extracellular camera which responds to a real image to generate a real image signal. The real image signal is cou ...

Wolfgang Fink, Mark Humayun: Method and system for training a visual prosthesis. California Institute of Technology, Doheny Eye Institute, Ropes & Gray, January 22, 2008: US07321796 (36 worldwide citation)

A method for training a visual prosthesis includes presenting a non-visual reference stimulus corresponding to a reference image to a visual prosthesis patient. The visual prosthesis including a plurality of electrodes. Training data sets are generated by presenting a series of stimulation patterns ...

Mark Humayun, Charles DeBoer, Ralph Kerns, Matthew McCormick, Prashant Bhadri, Lawrence Chong: Independent surgical center. Doheny Eye Institute, Knobbe Martens Olson & Bear, January 7, 2014: US08623000 (35 worldwide citation)

A biological tissue cutting and fluid aspiration system provides a plurality of surgical instruments operable independent of an external control console. In some embodiments, each surgical instrument may include all sensors and controls directly applicable to the surgical instrument, and may be used ...

Yu Chong Tai, Damien C Rodger, Wen Li, Mark Humayun, James D Weiland: Microfabricated devices for wireless data and power transfer. California Institute of Technology, Joseph R Baker Jr, Gavrilovich Dodd & Lindsey, March 23, 2010: US07684868 (33 worldwide citation)

This invention relates to the design and fabrication of micro electromechanical systems (MEMS) for applications in such varied fields as the biomedical, micro-fluidics and chemical analysis fields.

Mark Humayun, Charles DeBoer, Ralph Kerns, Matthew McCormick, Prashant Bhadri, Lawrence Chong: Independent surgical center. Doheny Eye Institute, Knobbe Martens Olson & Bear, May 15, 2012: US08177776 (32 worldwide citation)

A portable surgical tray unit can include a portable surgical tray for housing a processing unit, and that includes an opening extending entirely therethrough. The portable surgical tray unit can also include a plurality of instruments connected to the portable surgical tray and operably coupled to ...

Mark Humayun, Howard Phillips: Implants based on bipolar metal oxide semiconductor (MOS) electronics. University of Southern California, Fish & Richardson P C, November 9, 2010: US07831309 (32 worldwide citation)

Intraocular and periocular implantation devices based on one or more implantation electronic chips for implantation within the eye to include a bipolar MOS circuit that is DC biased at or near a natural electrical ground potential of the eye. Described examples include retinal prosthesis devices and ...