1
David L Rimm, Gregory Tedeschi, Robert L Camp, Mark Gustavson: Methods for making cancer prognoses based on subcellular localization of biomarkers. Yale University, Historx, Cooper & Dunham, John P White, May 4, 2010: US07709222 (13 worldwide citation)

This invention provides a method of making a prognosis for a patient afflicted with a type of cancer such as colon cancer, based upon quantification of biomarkers such as thymidylate synthase in subcellular compartments.


2
Jason Christiansen, Dylan M Reilly, Brian Bourke Martin, Mark Gustavson: Automatic exposure time selection for imaging tissue. HistoRx, Gilberto M Villacorta, Nikhil S Palekar, Foley & Lardner, July 12, 2011: US07978258 (9 worldwide citation)

The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is compos ...


3
Jason H Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Dylan M Reilly, Gregory R Tedeschi: Compartment segregation by pixel characterization using image data clustering. Historx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, December 18, 2012: US08335360 (4 worldwide citation)

The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator ...


4
Jason Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Gregory R Tedeschi, Dylan M Reilly, Maciej P Zerkowski, Christine Williams, Dongxiao Wang: Reproducible quantification of biomarker expression. Novartis, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, January 19, 2016: US09240043 (2 worldwide citation)

A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator.


5
Robert Pinard, Gregory R Tedeschi, Mark Gustavson: Method and system for determining an optimal dilution of a reagent. HistoRx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, February 21, 2012: US08121365 (1 worldwide citation)

A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment of the claimed method, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective pl ...


6
Jason H Christiansen, Robert Pinard, Mark Gustavson, Brian Bourke, Dylan M Reilly, Gregory R Tedeschi: Compartment segregation by pixel characterization using image data clustering. HistoRx, Gilberto M Villacorta, Daniel R Shelton, Foley & Lardner, February 18, 2014: US08655037

The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator ...


7
Mark Gustavson, Jennifer Giltnane, Marisa P Dolled Filhart, Robert L Camp, David L Rimm: Methods for determining signal transduction activity in tumors. HistoRx, Yale University, John P White, Cooper & Dunham, July 30, 2013: US08497080

The method of the invention pertains to determining signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transducti ...


8
Mark Gustavson, Jennifer Giltnane, Marisa P Dolled Filhart, Robert L Camp, David L Rimm: Methods for determining signal transduction activity in tumors. Historx, Yale University, John P White, Cooper & Dunham, February 5, 2013: US08367351

The method of the invention pertains to determining the signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transd ...


9
Robert Pinard, Gregory R Tedeschi, Mark Gustavson: Method and system for determining an optimal dilution of a reagent. HistoRx, Gilberto M Villacorta, Daniel Shelton, Foley & Lardner, December 10, 2013: US08605971

A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective plurality of immunoassay ...


10
David L Rimm, Gregory Tedeschi, Robert L Camp, Mark Gustavson: Methods for making cancer prognoses based on subcellular localization of biomarkers. Cooper & Dunham, January 31, 2008: US20080026415-A1

This invention provides a method of making a prognosis for a patient afflicted with a type of cancer such as colon cancer, based upon quantification of biomarkers such as thymidylate synthase in subcellular compartments.