1
Howard R Levin, Mark Gelfand: Renal nerve stimulation method and apparatus for treatment of patients. Ardian, Perkins Coie, January 9, 2007: US07162303 (422 worldwide citation)

A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. A ...


2
Mark Gelfand, Howard R Levin: Methods and devices for renal nerve blocking. Ardian, Perkins Coie, December 20, 2005: US06978174 (317 worldwide citation)

A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump eluting implant for targeted delivery of a nerve-blocking age ...


3
Mark Deem, Hanson Gifford III, Denise Demarais, Douglas Sutton, Erik Thai, Mark Gelfand, Howard R Levin: Methods and apparatus for renal neuromodulation. Ardian, Perkins Coie, January 26, 2010: US07653438 (312 worldwide citation)

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the ...


4
Denise Demarais, Nicolas Zadno, Benjamin J Clark, Erik Thai, Howard R Levin, Mark Gelfand: Methods and apparatus for thermally-induced renal neuromodulation. Ardian, Perkins Coie, November 10, 2009: US07617005 (297 worldwide citation)

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or ...


5
Denise Demarais, Nicolas Zadno, Benjamin J Clark, Erik Thai, Howard R Levin, Mark Gelfand: Methods and apparatus for thermally-induced renal neuromodulation. Ardian, Perkins Coie, May 18, 2010: US07717948 (275 worldwide citation)

Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or ...


6
Howard R Levin, Mark Gelfand: Renal nerve stimulation method and apparatus for treatment of patients. Ardian, Perkins Coie, January 12, 2010: US07647115 (248 worldwide citation)

A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. A ...


7
Denise Demarals, Hanson Gifford III, Mark Deem, Howard R Levin, Mark Gelfand, Nicolas Zadno: Methods and apparatus for monopolar renal neuromodulation. Ardian, Perkins Coie, March 6, 2012: US08131371 (223 worldwide citation)

Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or bl ...


8
Denise Demarais, Hanson Gifford III, Mark Deem, Douglas Sutton, Howard R Levin, Mark Gelfand: Methods for catheter-based renal denervation. Ardian, Perkins Coie, April 3, 2012: US08150520 (208 worldwide citation)

Methods and apparatus are provided for treating end-stage renal disease, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or e ...


9
Howard R Levin, Mark Gelfand, Steve Bernard: Kidney perfusion catheter. CHF Solutions, Nixon & Vanderhye P C, July 15, 2003: US06592567 (206 worldwide citation)

A kidney perfusion catheter assembly is disclosed having an introducer catheter, a renal artery seal, a perfusion tip, and a guide wire. The perfusion catheter provides a flow of supplemental blood to increase the local blood pressure in the renal artery and to perfuse the kidney. The introducer cat ...


10
Denise Demarais, Hanson Gifford III, Mark Deem, Douglas Sutton, Howard R Levin, Mark Gelfand: Methods and apparatus for bilateral renal neuromodulation. Ardian, Perkins Coie, April 3, 2012: US08150519 (202 worldwide citation)

Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or el ...



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