1
Ivan Osorio, Mark G Frei: Vagal nerve stimulation techniques for treatment of epileptic seizures. Banner & Witcoff, January 22, 2002: US06341236 (588 worldwide citation)

A system and method for using electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vag ...


2
Ivan Osorio, Mark G Frei: Vagal nerve stimulation techniques for treatment of epileptic seizures. Banner & Witcoff, December 30, 2003: US06671556 (334 worldwide citation)

The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus ...


3
Ivan Osorio, Mark G Frei: Vagal nerve stimulation techniques for treatment of epileptic seizures. Banner & Witcoff, July 1, 2003: US06587727 (237 worldwide citation)

The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus ...


4
Mark G Frei, Ivan Osorio, Mark T Rise, Jonathon E Giftakis, Nina M Graves, David L Carlson, Randy M Jensen: Channel-selective blanking for a medical device system. Medtronic, Banner & Witcoff, July 10, 2007: US07242983 (177 worldwide citation)

Apparatuses and methods selectively blank a neurological channel of a medical device system in the treatment of a nervous system disorder. A selected signal of a selected channel may be blanked if it is determined that the selected signal may be affected by an artifact when the medical device system ...


5
Ivan Osorio, Mark G Frei: Vagal nerve stimulation techniques for treatment of epileptic seizures. Donald R Schoonover, July 19, 2005: US06920357 (166 worldwide citation)

The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus ...


6
Ivan Osorio, Mark G Frei: Vagal nerve stimulation techniques for treatment of epileptic seizures. Flint Hills Scientific L L C, Donald R Schoonover, November 1, 2005: US06961618 (163 worldwide citation)

The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus ...


7
Alexei V Nikitin, Mark G Frei, Naresh C Bhavaraju, Ivan Osorio: Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes. Flint Hills Scientific L L C, Chase Law Firm L C, July 27, 2004: US06768969 (124 worldwide citation)

A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, o ...


8
Ivan Osorio, Naresh C Bhavaraju, Thomas E Peters, Mark G Frei, Jonathan C Werder: Synchronization and calibration of clocks for a medical device and calibrated clock. Medtronic, Banner & Witcoff, July 18, 2006: US07079977 (106 worldwide citation)

Apparatus and method support the synchronization and calibration of a plurality of clocks in a medical device system that may provide treatment to a patient with a nervous system disorder. The plurality of clocks, which may be located at different components of the medical device system, includes a ...


9
Alexei V Nikitin, Mark G Frei, Naresh C Bhavaraju, Ivan Osorio, Ruslan Davidchack: Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes. Flint Hills Scientific L L C, Chase Law Firm L C, June 7, 2005: US06904390 (88 worldwide citation)

A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, o ...


10
Ivan Osorio, Mark G Frei: Cerebral or organ interface system. Flint Hills Scientific, Donald R Schoonover, March 18, 2008: US07346391 (73 worldwide citation)

A cerebral and/or interface system has a housing mechanism configured to be at least partially spaced in a cavity formed in the subject's skull; an attaching mechanism for attaching the housing mechanism to the subject's skull; a sealing mechanism for providing a fluid-tight seal between the housing ...