1
Stephen E Moring, Kevin S Bodner, Jason H Halsey, Jon Hoshizaki, Joseph Jackson, Alfred P Madden, Mark F Oldham, Mark T Reed: Multi-well microfiltration apparatus. The Perkin Elmer Corporation, Jeffery D Iota Pi Law Group Frazier, December 12, 2000: US06159368 (94 worldwide citation)

The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including (i) a column plate havi ...


2
Howard G King, Steven J Boege, Eugene F Young, Mark F Oldham: Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength. Applied Biosystems, Leonnard D Bowersox, December 22, 2009: US07635588 (63 worldwide citation)

An apparatus and method are provided for differentiating multiple detectable signals by excitation wavelength. The apparatus can include a light source that can emit respective excitation light wavelengths or wavelength ranges towards a sample in a sample retaining region, for example, in a well. Th ...


3
Mark F Oldham, Austin B Tomaney: Image enhancement by sub-pixel imaging. Applera Corporation, Knobbe Martens Olson & Bear, January 29, 2008: US07323681 (52 worldwide citation)

Methods and apparatus for improving the resolution of an electronic imaging device having an array of pixels. Sub-pixel dimension movements between an object and the array of pixels are made, and an image is formed at each position. Resulting shifted images are combined to yield an effective resolut ...


4
Mark F Oldham, Howard G King, Douwe D Haga, Tracy L Ferea: Array imaging system. Applera Corporation, Harness Dickey & Pierce, November 14, 2006: US07135667 (51 worldwide citation)

An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus can comprise a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least a portion of the light can ill ...


5
Mark F Oldham, Austin B Tomaney: Image enhancement by sub-pixel imaging. Applera Corporation, Knobbe Martens Olson & Bear, April 3, 2007: US07199357 (47 worldwide citation)

Methods and apparatus for improving the resolution of an electronic imaging device having an array of pixels. Sub-pixel dimension movements between an object and the array of pixels are made, and an image is formed at each position. Resulting shifted images are combined to yield an effective resolut ...


6
Kevin S Bodner, Alfred P Madden, Joseph Jackson, Jason H Halsey, Mark T Reed, Ward Frye, Mark F Oldham, Stephen E Moring, Jon Hoshizaki: Multi-well microfiltration apparatus. PE Corporation, Kilyk & Bowersox P L L C, January 15, 2002: US06338802 (43 worldwide citation)

The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including (i) a column plate havi ...


7
Mark F Oldham, Eugene F Young: Instrument for monitoring nucleic acid sequence amplification reaction. Applied Biosystems, Kilyk & Bowersox P L L C, March 3, 2009: US07498164 (40 worldwide citation)

An instrument is provided that can monitor nucleic acid sequence amplifications reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided ...


8
Mark F Oldham, Richard D Morris, Jerome A Mack: Sample carrier device incorporating radio frequency identification, and method. Applera Corporation, Kilyk & Bowersox P L L C, June 3, 2008: US07382258 (38 worldwide citation)

An apparatus for associating information with a carrier and/or at least one biological reagent is provided. The apparatus can include a carrier adapted to retain at least one biological reagent and at least one non-silicon Radio Frequency Identification Tag (RFID). The RFID tag can comprise informat ...


9
Richard T Reel, Mark F Oldham, Eric S Nordman, Steven J Boege, Steven M Menchen: Systems, methods and apparatus for single molecule sequencing. Applied Biosystems, Life Technologies Corporation, May 4, 2010: US07709808 (38 worldwide citation)

An embodiment generally relates to a system for analysis of an analyte. The system can include a transparent substrate. The system also includes an excitation light source configured to induce an evanescent wave excitation of a fluorescently labeled molecule near the access to the transparent substr ...


10
Austin B Tomaney, Mark F Oldham: Signal noise reduction for imaging in biological analysis. Applera Corporation, Kilyk & Bowersox P L L C, June 19, 2007: US07233393 (36 worldwide citation)

A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the methods ...