1
Marvin H Caruthers, Mark D Matteucci: Process for preparing polynucleotides. University Patents, George M Yahwak, July 3, 1984: US04458066 (892 worldwide citation)

New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).


2
Marvin H Caruthers, Mark D Matteucci: Nucleosides useful in the preparation of polynucleotides. University Patents, George M Yahwak, February 19, 1985: US04500707 (362 worldwide citation)

New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).


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Mark D Matteucci, Xiaodong Cao: Binding compentent oligomers containing unsaturated 3,5 and 2,5 linkages. Gilead Sciences, Daryl D Muenchau, July 18, 1995: US05434257 (264 worldwide citation)

Oligonucleotide analogs having one or more substitute linkages of the formula 2'/3'--S--CH.sub.2 --CH.dbd.5' or 2'/3'--O--CH.sub.2 --CH.dbd.5' between adjacent nucleomonomers are disclosed. The substitute linkage replace the usual phosphodiester linkage found in unmodified nucleic acids. The oligonu ...


5
Norbert W Bischofberger, Mark D Matteucci: Nucleic acid intercalating agents. Genentech, Daryl B Winter, Max D Hensley, December 29, 1992: US05175273 (243 worldwide citation)

Pyridinone or pyrimidinone nucleoside bases containing fused aromatic polycyclic rings are provided. These polycyclic nucleosides are incorporated into oligonucleotides and hybridized to complementary nucleic acid. Fluorescence spectroscopy and thermal denaturation profiles provided evidence that th ...


6
Mark D Matteucci, Robert J Jones: Pyrimidine derivatives for labeled binding partners. Gilead Sciences, Max D Hensley, June 9, 1998: US05763588 (225 worldwide citation)

Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) ##STR1## wherein R.sup.1 is a binding partner, a linker or H; a and b are 0 or 1, provided that the total of a and b is 0 or 1;


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Kuei Ying Lin, Mark D Matteucci: Pyrimidine derivatives and oligonucleotides containing same. Gilead Sciences, Woodcock Washburn Kurtz Mackiewicz & Norris, February 22, 2000: US06028183 (136 worldwide citation)

Compounds having structure (1) ##STR1## wherein R.sup.1 is --H a protecting group, a linker or a binding partner; and R.sup.2 and R.sup.34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compou ...


9
Mark D Matteucci, Jiancun Zhang: Method for oligonucleotide analog synthesis. Gilead Sciences, Daryl D Muenchau, July 8, 1997: US05646269 (125 worldwide citation)

The present invention is directed to improved methods to synthesize oligonucleotide analogs having an acetal linkage, such as a 3',5'-formacetal (3' --O--CH.sub.2 --O-- 5'), 3',5'-thioformacetal (3' --S--CH.sub.2 --O-- 5') or an analogous 2',5' linkage between adjacent nucleoside analog residues. Co ...


10
Kuei Ying Lin, Mark D Matteucci: Pyrimidine derivatives for labeled binding partners. Gilead Sciences, Woodcock Washburn Kurtz Mackiewicz & Norris, December 28, 1999: US06007992 (122 worldwide citation)

Compounds having structure (1) ##STR1## wherein R.sup.1 is --H a protecting group, a linker or a binding partner; and R.sup.2 and R.sup.34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compou ...