1
Mark Carle Connelly, Gerald V Doyle, Galla Chandra Rao, Leon W M M Terstappen: Method for assessing disease states by profile analysis of isolated circulating endothelial cells. Veridex, March 8, 2011: US07901950 (33 worldwide citation)

Elevated number of Circulating Endothelial Cells (CEC) have been implicated in disease conditions associated with the formation or destruction of blood vessels such as acute coronary syndrome, thrombocytopenic purpura, sickle cell disease, sepsis, lupus, nephrotic syndromes, rejection of organ trans ...


2
Mark Carle Connelly, Mark Kopnitsky: Method and composition for homogeneous multiplexed microparticle-based assay. Zeus Scientific, Joseph F Aceto Esq, James L Wilcox Esq, March 9, 2010: US07674632 (3 worldwide citation)

A method and composition for detecting and measuring analytes, such as antibodies, which are capable of binding with certain binding partners such as antigens. A homogenous assay is performed in the presence of free unbound antibodies. Such a homogeneous assay testing for specific antibodies is here ...


3
Antonio Gualberto, Maria Luisa Paccagnella, Carrie L Melvin, Madeline I Repollet, David Chianese, Mark Carle Connelly, Leonardus Wendelinus Mathias Marie Terstappen: Circulating tumor cell assay. Veridex, Pfizer, Ropes & Gray, January 27, 2015: US08940493 (1 worldwide citation)

Methods for the detection, enumeration and analysis of circulating tumor cells expressing insulin-like growth factor-1 receptors (IGF-1R) are disclosed. These methods are useful for cancer screening and staging, development of treatment regimens, and for monitoring for treatment responses, cancer re ...


4
John A Verrant, Arjan G J Tibbe, Brad Foulk, Joost F Swennenhuis, Leon W M M Terstappen, Mark Carle Connelly, Michael T Kagan: System for the detection and enumeration of suspect target cells in a mixed cell population. Janssen Diagnostics, September 8, 2015: US09127302 (1 worldwide citation)

The invention relates generally to the field of identification of DNA sequences, genes or chromosomes. Methods and composition to obtain Unique Sequence DNA probes are provided. Composition comprises of any double stranded DNA containing Unique Sequences from which the repetitive sequences are elimi ...


5
Mark Carle Connelly, Frank Coumans, Steve Gross, Mike Kelly: High sensitivity multiparameter method for rare event analysis in a biological sample. Janssen Diagnotics, September 15, 2015: US09134237 (1 worldwide citation)

A sample of blood containing CTCs, or other cells of interest, is stained with fluorescent markers for image analysis and scanned to identify the presence and location within the cartridge of target cells or subcellular elements. A sample containing desired target cells or subcellular elements is th ...


6
John Verrant, Mark Carle Connelly, Brad Foulk, Michael T Kagan, Joost F Swennenhuis, Leon W M M Terstappen, Arjan G J Tibbe: Methods and composition to generate unique sequence DNA probes, labeling of DNA probes and the use of these probes. Menarini Silicon Biosystems, Foley & Lardner, May 1, 2018: US09957571

The invention relates generally to the field of the identification of DNA sequences, genes or chromosomes. Methods and composition to obtain Unique Sequence DNA probes are provided. Compositions comprises of and double stranded DNA containing Unique Sequences from which the repetitive sequences are ...


7
Steven Gross, Mark Carle Connelly, Galla Chandra Rao, Marielena Mata, Carrie Morano: Assay to capture and detect circulating multiple myeloma cells from blood. Janssen Diagnostics, April 11, 2017: US09618515

The invention includes methods for isolating circulating multiple myeloma cells as well as method of treating patients suspected of having diseases of abnormal plasma cells.


8
Mark Carle Connelly, Gerald V Doyle, Galla Chandra Rao, Leon WMM Terstappen: Method for assessing disease states by profile analysis of isolated circulating endothelial cells. Immunicon Corporation, July 5, 2007: US20070154960-A1

Elevated number of Circulating Endothelial Cells (CEC) have been implicated in disease conditions associated with the formation or destruction of blood vessels such as acute coronary syndrome, thrombocytopenic purpura, sickle cell disease, sepsis, lupus, nephrotic syndromes, rejection of organ trans ...


9
Mark Carle Connelly, Mark Kopnitsky: Composition for homogeneous multiplexed microparticle-based assay. Zeus Scientific, Sperry Zoda And Kane, November 23, 2006: US20060263836-A1

A method and composition for the purpose of detecting and measuring analytes, such as antibodies, which are capable of binding with certain binding partners such as antigens. A homogenous assay is performed in the presence of free unbound antibodies. Such a homogeneous assay testing for specific ant ...


10
Mark Carle Connelly, Gerald V Doyle, Galla Chandra Rao, Leon WMM Terstappen: Method of assessing metastatic carcinomas from circulating endothelial cells and disseminated tumor cells. Philip S Johnson, Johnson & Johnson, July 30, 2009: US20090191535-A1

A method for assessing cancer in test subjects is described based upon enumeration of circulating endothelial cells and/or disseminated tumor cells in a test subject. This method is used to quantify disseminated tumor cells. Correlations with circulating tumor cells provides prognostic information w ...