1
James H Brauker, Victoria Carr Brendel, Paul V Neale, Laura A Martinson, Mark A Tapsak: Optimized sensor geometry for an implantable glucose sensor. DexCom, Knobbe Martens Olson & Bear, November 14, 2006: US07134999 (736 worldwide citation)

An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such tha ...


2
James H Brauker, Mark C Shults, Mark A Tapsak: Membrane for use with implantable devices. Dexcom, Knobbe Martens Olson & Bear, March 9, 2004: US06702857 (719 worldwide citation)

The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer f ...


3
James H Brauker, Victoria Carr Brendel, Mark A Tapsak: Porous membranes for use with implantable devices. DexCom, Knobbe Martens Olson & Bear, March 20, 2007: US07192450 (661 worldwide citation)

A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular atta ...


4
Peter C Simpson, Paul Goode, Mark A Tapsak, Victoria Carr Brendel: Electrochemical sensors including electrode systems with increased oxygen generation. DexCom, Knobbe Martens Olson & Bear, September 19, 2006: US07108778 (660 worldwide citation)

The present invention relates generally to systems and methods for increasing oxygen generation in electrochemical sensors in order to overcome the oxygen limitations. The preferred embodiments employ electrode systems with at least two electrodes in relatively close proximity to each other; wherein ...


5
Mark C Shults, Stuart J Updike, Rathbun K Rhodes, Barbara J Gilligan, Mark A Tapsak: Device and method for determining analyte levels. DexCom, Knobbe Martens Olson & Bear, March 1, 2005: US06862465 (628 worldwide citation)

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices incl ...


6
Mark A Tapsak, Rathbun K Rhodes, Mark C Shults, Jason D McClure: Techniques to improve polyurethane membranes for implantable glucose sensors. DexCom, Knobbe Martens Olson & Bear, June 5, 2007: US07226978 (556 worldwide citation)

The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observab ...


7
James H Brauker, Mark A Tapsak, Sean T Saint, Apurv U Kamath, Paul V Neale, Peter C Simpson, Michael Robert Mensinger, Dubravka Markovic: Integrated delivery device for continuous glucose sensor. Dexcom, Knobbe Martens Olson and Bear, September 22, 2009: US07591801 (554 worldwide citation)

Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) ...


8
Mark C Shults, Stuart J Updike, Rathbun K Rhodes, Barbara J Gilligan, Mark A Tapsak: Device and method for determining analyte levels. DexCom, Knobbe Martens Olson & Bear, November 14, 2006: US07136689 (480 worldwide citation)

Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices incl ...


9
Rathbun Rhodes, Mark A Tapsak, James H Brauker, Mark C Shults: Sensor head for use with implantable devices. DexCom, Knobbe Martens Olson & Bear, December 30, 2008: US07471972 (448 worldwide citation)

The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-con ...


10
James H Brauker, Mark C Shults, Mark A Tapsak: Membrane for use with implantable devices. DexCom, Knobbe Martens Olson & Bear, December 15, 2009: US07632228 (424 worldwide citation)

The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer f ...