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Marino Nebuloni, Patrizia Colombo: Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride. TONIX PHARMA HOLDINGS, Ropes & Gray, May 2, 2017: US09636408

The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol or Amitriptyline HCl and mannitol.


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Alberto Milanese, Marino Nebuloni, Lucia Carrano: Complex of amorphous tomoxiprole and cyclodextrin with fast dissolution rate and process for the preparation thereof. Fondazione Istituto Insubrico di Ricerca per la Vita, Fondazione Cariplo, Silvia Salvadori P C, July 29, 2014: US08791269

A stable complex of tomoxiprole with 2-hydroxypropyl-beta-cyclodextrin with fast dissolution rate and rapid absorption wherein amorphous tomoxiprole forms a complex with 2-hydroxypropyl-beta-cyclodextrin in about equimolecular ratio. The complex shows a remarkably faster dissolution rate and absorpt ...


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Bruno Cavalleri, Emilio Occelli, Marino Nebuloni: Rifapentine hydrohalides. Gruppo Lepetit, DAI ZHENXIU, February 7, 1990: CN89104777

The acid addition salt of rifapentine with hydrochloric and hydrobromic acid are obtained from the as free bases and hydrohalic acid aqueous solutions. The crystallization from different organic solvents or precipitation from solvents by addition of non solvents yield two distinct polymorphs and the ...


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