1
Pierandrea Esposito, Nicoletta Coceani, Maria Dorly Del Curto, Fabio Carli: Biphasic multicomponent pharmaceutical dosage forms containing substances able to modify the partitioning of drugs. Eurand International S p A, Thompson Hine, December 17, 2002: US06495160 (29 worldwide citation)

The invention provides a biphasic multicomponent pharmaceutical composition consisting of an oil phase and a water phase, comprising one or more lipophilic or oil carrier, one or more hydrophilic or aqueous carrier, one or more ionic or nonionic type surfactant, one or more cosurfactant, one or more ...


2
Maria Dorly Del Curto, Daniela Chicco, Pierandrea Esposito: Lipid microparticles by cryogenic micronization. Ares Trading, Browdy and Neimark PLLC, April 27, 2010: US07704525 (1 worldwide citation)

This invention relates to Lipid Microparticles consisting of lipids enriched in amphiphilic components, which promote the incorporation of peptides and/or protein, process for obtaining them as well as use thereof. A cryogenic micronization manufacturing process for their preparation is also disclos ...


3
Maria Dorly Del Curto, Ilaria Zambaldi, Silvia Pompili, Pierandrea Esposito: Hydrogel interferon formulations. Ares Trading, Saliwanchik Lloyd & Saliwanchik, February 1, 2011: US07879320

The present invention is related to pharmaceutical Poloxamer hydrogel formulations containing an interferon. In particular, the invention relates to sustained release hydrogel formulations of interferon-beta, method of preparation and use thereof.


4
Maria Dorly Del Curto: Stabilized interferon liquid formulations. Ares Trading, Saliwanchik Lloyd & Saliwanchik, December 7, 2010: US07846427

Stabilized liquid pharmaceutical composition comprising an interferon (IFN) or an isoform, mutein, fused protein, functional derivative, active fraction or salt thereof, wherein said formulation is a solution that comprises a buffer, a cyclodextrin, an isotonicity agent and an anti-oxidant are descr ...


5
Maria Dorly Del Curto, Daniela Chicco, Pierandrea Esposito: Lipid microparticles by cryogenic micronization. Browdy And Neimark Pllc, May 13, 2004: US20040091522-A1

This invention relates to Lipid Microparticles consisting, of lipids enriched in amphiphilic components, which promote the incorporation of peptides and/or protein, process for obtaining them as well as use thereof. A cryogenic micronization manufacturing process for their preparation is also disclo ...


6
Maria Dorly Del Curto: Stabilized interferon liquid formulations. Saliwanchik Lloyd & Saliwanchik, A Professional Association, May 10, 2007: US20070104682-A1

Stabilized liquid pharmaceutical composition comprising an interferon (IFN) or an isoform, mutein, fused protein, functional derivative, active fraction or salt thereof, wherein said formulation is a solution that comprises a buffer, a cyclodextrin, an isotonicity agent and an anti-oxidant are descr ...


7
Pierandrea Esposito, Nicoletta Coceani, Fabio Carli, Maria Dorly Del Curto: Biphasic multicomponent pharamaceutical dosage forms containing substances able to modify the partitioning of drugs. Mark P Levy, Thompson Hine & Flory, March 21, 2002: US20020034539-A1

Biphasic multicomponent pharmaceutical compositions, consisting of an oil phase and a water phase comprising compounds able to modifiy the partition of the active principles between said phases and their percutaneous, transdermal and transmucosal adsorption.


8
Maria Dorly Del Curto, Ilaria Zambaldi, Silvia Pompili, Pierandrea Esposito: Hydrogel Interferon Formulations. Ares Trading, Saliwanchik Lloyd & Saliwanchik, A Professional Association, October 25, 2007: US20070248674-A1

The present invention is related to pharmaceutical Poloxamer hydrogel formulations containing an interferon. In particular, the invention relates to sustained release hydrogel formulations of interferon-beta, method of preparation and use thereof.


9
Maria Dorly Del Curto, Daniela Chicco, Pierandrea Esposito: Amphiphilic lipid nanoparticles for peptide and/or protein incorporation. Browdy And Neimark Pllc, April 29, 2004: US20040081688-A1

Lipid nanoparticles loaded with drugs, such as peptides or proteins, are herein described. A process for obtaining them as well as their use for the preparation of a pharmaceutical composition is also disclosed. According to a preferred embodiment, the drug is a LHRH analogue, more preferably a LHRH ...


10
Maria Edvige Sangalli, Gianaldo Tavella, Maria Dorly Del Curto, Andrea Gazzaniga, Alessandra Maroni, Luca Palugan, Lucia Zema, Maddalena Spreafico: System for the colon delivery of drugs subject to enzyme degradation and/or poorly absorbed in the gastrointestinal tract. October 13, 2011: US20110250238-A1

Said invention refers to a pharmaceutical form for selective colon delivery of drugs or bioactive molecules degraded and/or poorly absorbed in the gastrointestinal tract. The system comprises a core consisting of the active ingredient, and a protease inhibitor layer and/or an absorption enhancer lay ...