1
Mossa Albert Carmelo, Goven Lisa May, Atwood John Girdner, Williams Fenton, Woudenberg Timothy M, Margulies Marcel, Ragusa Robert P, Leath Richard: Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control.. Perkin Elmer Cetus Instr, June 3, 1992: EP0488769-A2 (92 worldwide citation)

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow throu ...


2
Mossa Albert Carmelo, Goven Lisa May, Atwood John Girdner, Williams Fenton, Woudenberg Timothy M, Margulies Marcel, Ragusa Robert P, Leath Richard: Apparatus and containers for performing polymerase chain reaction. Perkin Elmer, December 3, 1997: EP0810030-A1 (21 worldwide citation)

A thermocycler apparatus for performing polymerase chain reaction (PCR) comprises a heating block (12) and heated cover (14) in which sample tubes (324,326) are retained, heated and cooled as required. The heating of the upper portions and caps of sample tubes (324,326) in use prevents condensation ...


3
Mossa Albert Carmelo, Goven Lisa May, Atwood John Girdner, Williams Fenton, Woudenberg Timothy M, Margulies Marcel, Ragusa Robert P, Leath Richard: Automated performance of polymerase chain reaction. Perkin Elmer, November 28, 2001: EP1157744-A1 (13 worldwide citation)

Apparatus for performing quantitative PCR has wells formed in a metal sample block, constant bias cooling to cool the block uniformly at a rate of 0.1 DEG C/sec and computer controlled uniform heating of the sample block at a rate greater than the rate of cooling in the absence of heating.


4
Mossa Albert, Woudenberg Timothy M, Goven Lisa, Margulies Marcel, Atwood John Girdner, Ragusa Robert, Williams Fenton, Leath Richard: Performing polymerase chain reaction. Applera, March 2, 2005: EP1510823-A2 (12 worldwide citation)

Disposable polypropylene tubes are used as reaction containers for performing polymerase chain reaction (PCR) on samples of nucleic acids. The tubes have a lower conical portion and an upper cylindrical portion. The tubes are capped in use. The lower portion contacts a correspondingly shaped hole in ...


5
Mossa Albert Carmelo, Goven Lisa May, Atwood John Girdner, Williams Fenton, Woudenberg Timothy M, Margulies Marcel, Ragusa Robert P, Leath Richard: Automated performance of the polymerase chain reaction. Perkin Elmer, December 17, 1997: EP0812621-A1 (11 worldwide citation)

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow throu ...


6
Margulies Marcel: Quadrupole mass filter for charged particles.. Perkin Elmer, September 11, 1991: GB2241821-A (3 worldwide citation)

A mass filter for charged particles includes a cylindrical conductive housing at ground potential and an array of linear conductors arranged in parallel in the housing and divided equally into four subarrays. The conductors of each subarray lie in one of four planes having a tubular arrangement with ...


7
Mossa Albert C, Goven Lisa M, Atwood John G, Williams Fenton, Woudenberg Timothy M, Margulies Marcel, Ragusa Robert P, Leath Richard: Systeme de cyclage thermique pour optimiser par voie automatique la pcr avec regulation precise de la temperature, Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control. Perkin Elmer Cetus Instruments, BORDEN LADNER GERVAIS, April 13, 1999: CA2056743 (3 worldwide citation)

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow throu ...


8
Mossa Albert, Goven Lisa, Atwood John Girdner, Williams Fenton, Woudenberg Timothy M, Margulies Marcel, Ragusa Robert, Leath Richard: Containers for performing polymerase chain reaction. Pe Corp Ny, January 15, 2003: EP1275438-A2 (2 worldwide citation)

Disposable polypropylene tubes are used as reaction containers for performing polymerase chain reaction (PCR) on samples of nucleic acids. The tubes have a lower conical portion and an upper cylindrical portion. The tubes are capped in use. The lower portion contacts a correspondingly shaped hole in ...


9
Mccorkle E Joel, Vogel Herman, Margulies Marcel, Ferranti Richard T: Apparatus for controlling level of cryogenic liquid. Perkin Elmer, June 4, 1997: EP0777078-A1 (1 worldwide citation)

An apparatus for controlling level of cryogenic liquid in a vessel includes a transfer duct to a pressure supply tank. Pressure pulses are applied to the tank at one rate when the level is below a primary sensor in the vessel, and at a lower rate when the level is above the sensor, so as to compensa ...


10
Schawe Juergen, Margulies Marcel: Apparatus and method for differential analysis using real and imaginary signal components. Perkin Elmer, October 29, 1997: EP0803061-A1

The invention is directed to a differential analysis method and apparatus wherein a sample and reference are subjected to an externally applied disturbance, such as temperature change, in accord with a temperature program comprising two or more linear segments of equal time duration, and the measure ...