1
Neelima M Bhat, Marcia M Bieber, Nelson N H Teng: Method of killing B cells using antibodies which bind CDIM. The Leland Stanford Junior University, Cooley Godward, January 14, 1997: US05593676 (54 worldwide citation)

Methods are provided for inducing cell death in B-cells, including neoplastic B-cells, by employing reagents that bind to a B-cell epitope. Particularly, antibodies specific for the marker can be administered to a host to induce death in B-cells to which the antibodies bind or can be used in ex vivo ...


2
Nelson N H Teng, Neelima M Bhat, Marcia M Bieber: Triple gradient process for recovering nucleated fetal cells from maternal blood. The Board of Trustees of the Leland Stanford Junior University, Bertram I Rowland, January 4, 1994: US05275933 (22 worldwide citation)

Nucleated fetal cells such as nucleated fetal red blood cells are separated from maternal blood with a discontinuous triple gradient gel and centrifugation. Nucleated fetal red blood cells are collected at an interface between a gel layer having a density in the range of from 1.105 to 1.110 g/mL and ...


3
Neelima M Bhat, Marcia M Bieber, Nelson N H Teng: Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM. The Board of Trustees of the Leland Stanford Junior University, Cooley Godward Castro Huddleson & Tatum, May 23, 1995: US05417972 (12 worldwide citation)

Methods are provided for inducing cell death in B-cells, including neoplastic B-cells, by employing reagents that bind to a B-cell epitope. Particularly, antibodies specific for the marker can be administered to a host to induce death in B-cells to which the antibodies bind or can be used in ex vivo ...


4
Neelima M Bhat, Marcia M Bieber, Nelson N H Teng, Martin E Sanders: Antibody induced cell membrane wounding. The Board of Trustees of the Leland Stanford Junior University, Birgit Millauer Esq, Chao Hadidi Stark & Barker, February 19, 2013: US08377435 (2 worldwide citation)

Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated w ...


5
Nelson N H Teng, Neelima M Bhat, Marcia M Bieber, Bruce A Keyt: CDIM binding proteins and uses thereof. IGM BIOSCIENCES, Chao Hadidi Stark & Barker, Birgit Millauer, August 9, 2016: US09409976

The present disclosure relates to Cell Death Inducing Molecule (“CDIM”) binding proteins and pharmaceutical compositions thereof. Particularly, the disclosure provides CDIM binding proteins that are useful in the selective depleting and killing of B cells, including neoplastic B cells as well as neo ...


6
Neelima M Bhat, Marcia M Bieber, Nelson N H Teng, Martin E Sanders: Antibody induced cell membrane wounding. IGM BIOSCIENCES, Chao Hadidi Stark & Barker, Birgit Millauer, October 4, 2016: US09458241

Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated w ...


7
Neelima M Bhat, Marcia M Bieber, Nelson N H Teng, Martin E Sanders: Enhanced b cell cytotoxicity of cdim binding antibody. Palingen, Univ Leland Stanford Junior, July 26, 2006: EP1682179-A2

Formulations and methods of treating human patients suffering from a condition characterized by lymphoid cancer, autoimmune disease or B cell hyperproliferation are disclosed, the treatment comprising administering (1) a cytotoxic amount of an antibody having specific binding for CDIM epitopes on a ...


8
Neelima M Bhat, Marcia M Bieber, Nelson NH Teng, Martin E Sanders: Enhanced B cell cytotoxicity of CDIM binding antibody. Cynthia Ruth Moore, May 26, 2005: US20050112130-A1

Formulations and methods of treating human patients suffering from a condition characterized by lymphoid cancer, autoimmune disease or B cell hyperproliferation are disclosed, the treatment comprising administering (1) a cytotoxic amount of an antibody having specific binding for CDIM epitopes on a ...


9
Neelima M Bhat, Marcia M Bieber, Nelson NH Teng, Martin E Sanders: Antibody induced cell membrane wounding. Cynthia Ruth Moore, July 13, 2006: US20060153854-A1

Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated w ...


10
Neelima M Bhat, Marcia M Bieber, Nelson NH Teng, Martin E Sanders: Enhanced b cell cytotoxicity of cdim binding antibody. Moore Patents, December 23, 2010: US20100322849-A1

Formulations and methods of treating human patients suffering from a condition characterized by lymphoid cancer, autoimmune disease or B cell hyperproliferation are disclosed, the treatment comprising administering (1) a cytotoxic amount of an antibody having specific binding for CDIM epitopes on a ...