1
Stephen Quake, Marc Unger: Methods and apparatus for analyzing polynucleotide sequences. California Institute of Technology, Proskauer Rose, November 16, 2004: US06818395 (247 worldwide citation)

Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.


2
Stephen Quake, Wayne Volkmuth, Marc Unger: Methods and apparatus for analyzing polynucleotide sequences. California Institute of Technology, Proskauer Rose, June 28, 2005: US06911345 (222 worldwide citation)

The present invention provides an apparatus for analyzing the sequences of polynucleotides. The apparatus comprises (a) flow cell which has at least one microfabricated multilayer elastomeric synthesis channel; and (b) an inlet port and an outlet port. The inlet port and outlet ports are in fluid co ...


3
Marc Unger, Ian D Manger, Michael Lucero, Yong Yi, Emily Miyashita Lin, Anja Weinecke, Geoffrey Facer: Microfluidic device and methods of using same. Fluidigm Corporation, Townsend and Townsend and Crew, October 10, 2006: US07118910 (211 worldwide citation)

A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which r ...


4
Marc Unger, Jiang Huang, Emerson Quan: Microfluidic devices and methods of using same. Fluidigm Corporation, Townsend and Townsend and Crew, January 13, 2009: US07476363 (138 worldwide citation)

An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming ...


5
Marc Unger: Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes. Fluidigm Corporation, Townsend and Townsend and Crew, November 6, 2007: US07291512 (100 worldwide citation)

A valve structure comprises an elastomeric block formed with first and second microfabricated recesses separated by a membrane portion of the elastomeric block. The valve is actuated by positioning a compliant electrode on a first side of the first recess proximate to and in physical communication w ...


6
Lincoln McBride, Michael Lucero, Marc Unger, Hany Ramez Nassef, Geoffrey Facer: Microfluidic device and methods of using same. Fluidigm Corporation, Townsend and Townsend and Crew, November 23, 2010: US07837946 (94 worldwide citation)

A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyzes. Some devices also include reaction sites located at the end of blind channels at which r ...


7
Marc Unger, Ian D Manger, Michael Lucero, Yong Yi, Emily Miyashita Lin, Anja Wienecke, Geoffrey Facer: Microfluidic device and methods of using same. Fluidigm Corporation, Townsend and Townsend and Crew, October 26, 2010: US07820427 (93 worldwide citation)

A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which r ...


8
Lincoln McBride, Michael Lucero, Marc Unger, Hany Ramez Nassef, Geoffrey Facer, Yong Yi: Microfluidic device and methods of using same. Fluidigm Corporation, Townsend and Townsend and Crew, April 6, 2010: US07691333 (93 worldwide citation)

A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which r ...


9
Lincoln McBride, Geoffrey Facer, Marc Unger, Michael Lucero, Hany Ramez Nassef: Thermal reaction device and method for using the same. Fluidigm Corporation, Townsend and Townsend and Crew, July 6, 2010: US07749737 (90 worldwide citation)

An M times.N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for fo ...


10
Lincoln McBride, Marc Unger, Michael Lucero, Hany Ramez Nassef, Geoff Facer, Yong Yi: Microfluidic devices and methods of using same. Fluidigm Corporation, Townsend and Townsend and Crew, February 23, 2010: US07666361 (88 worldwide citation)

A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which r ...