1
Abraham J Domb, Alain Shikani, Andrew S T Haffer, Manoj Maniar: Anti-infective and anti-inflammatory releasing systems for medical devices. Leonard Bloom, Leonard Bloom, April 30, 1996: US05512055 (245 worldwide citation)

Devices are provided having a polymer coating incorporating compounds inhibiting inflammation and infection, along with subsequent tissue growth onto and around the device. Preferred embodiments include catheters, tubes, and implants that abut tissue following implantation into the body, especially ...


2
Manoj Maniar, Abraham J Domb: Controlled released microparticulate delivery system for proteins. Massachusetts Institute of Technology, Arnall Golden & Gregory, January 9, 1996: US05482927 (79 worldwide citation)

An improved surface erodible controlled release composition and the manufacturing thereof, for the continuous administration of biologically active proteins or peptide fragments, is described. The biologically active protein is dissolved in water or a suitable solvent, alone or in combination with s ...


3
Abraham J Domb, Manoj Maniar: Liposphere delivery systems for local anesthetics. Nova Pharmaceutical Corporation, Kilpatrick & Cody, July 13, 1993: US05227165 (52 worldwide citation)

A local anesthetic microsuspension system is disclosed that includes lipospheres, that are solid, water-insoluble microparticles that have a layer of a phospholipid embedded on their surface. The core of the liposphere is a solid anesthetic such as lidocaine or marcaine, or an anesthetic dispersed i ...


4
Abraham J Domb, Manoj Maniar: Branched polyanhydrides. Nova Pharmaceutical Corporation, Kilpatrick & Cody, December 29, 1992: US05175235 (35 worldwide citation)

Branched polyanhydrides that have superior properties for use in the controlled delivery of substances, prepared by the polymerization of a dicarboxylic acid monomer and a branching agent. The branching agent is a polycarboxylic acid monomer such as 1,3,5-benzenetricarboxylic acid ("BTC"), or an oli ...


5
Abraham J Domb, Manoj Maniar: Branched polyanhydrides. Nova Pharmaceutical Corporation, Kilpatrick & Cody, August 31, 1993: US05240963 (29 worldwide citation)

Branched polyanhydrides that have superior properties for use in the controlled delivery of substances, prepared by the polymerization of a dicarboxylic acid monomer and a branching agent. The branching agent is a polycarboxylic acid monomer such as 1,3,5-benzenetricarboxylic acid ("BTC"), or an oli ...


6
Abraham J Domb, Manoj Maniar: Fatty acid terminated polyanhydrides. Nova Pharmaceutical Corporation, Kilpatrick & Cody, January 12, 1993: US05179189 (19 worldwide citation)

Fatty acid terminated polyanhydrides suitable for use as controlled release matrices in biodegradable sustained release drug delivery systems and methods for making thereof are described. The polymers are more soluble in organic solvents, and have a lower melting point than the corresponding non-fat ...


7
Abraham J Domb, Manoj Maniar: Fatty acid terminated polyanhydride. Nova Pharmaceutical Corporation, Kilpatrick & Cody, May 31, 1994: US05317079 (12 worldwide citation)

Fatty acid terminated polyanhydrides suitable for use as controlled release matrices in biodegradable sustained release drug delivery systems and methods for making thereof are described. The polymers are more soluble in organic solvents, and have a lower melting point than the corresponding non-fat ...


8
Abraham J Domb, Manoj Maniar, Andrew S T Haffer: Biodegradable polymer blends for drug delivery. Massachusetts Institute of Technology, Arnall Golden & Gregory, July 6, 1999: US05919835 (12 worldwide citation)

Blends of polymers having properties distinct from the individual polymer components and that are suitable for use as carriers of pharmaceutically active agents, are prepared from two or more polyanhydrides, polyesters or mixtures of polyanhydrides and polyesters. The blends have different propertie ...


9
Manoj Maniar, Steven Mauch: Protected biopolymers for oral administration and methods of using same. Trega Biosciences, Campbell & Flores, December 8, 1998: US05846525 (2 worldwide citation)

The present invention provides a composition comprising an ion exchange resin and a therapeutically active biopolymer in a form for oral administration. The present invention also provides a composition comprising Amberlite.RTM. IRP-64 and a cytokine regulatory agent having the amino acid sequence:


10
Stanley C Bell, Albert Wong, Manoj Maniar: Formulations for parenteral administration of (e)-2, 6-dialkoxystyryl 4-substituted benzylsulfones. Onconova Therapeutics, Houri Khalilian, Law Offices of Khalilian Sira, November 22, 2011: US08063109 (1 worldwide citation)

Formulations are provided for parenteral administration of (amino substituted (e)-2,6-dialkoxystyryl 4-substituted benzylsulfones and the sodium and potassium salts thereof for the prevention and/or treatment of conditions mediated by abnormal cell proliferation. Composition for parenteral administr ...



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