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Butora Gabor, Guiadeen Deodialsingh, Kothandaraman Shankaran, Maccoss Malcolm, Mills Sander G, Yang Lihu: Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity. Merck & Co, Butora Gabor, Guiadeen Deodialsingh, Kothandaraman Shankaran, Maccoss Malcolm, Mills Sander G, Yang Lihu, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, August 11, 2005: WO/2005/072361 (38 worldwide citation)

Compounds of Formula I and Formula II (wherein A, E, j, k, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, X, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the preven ...


13
Greenlee William J, Johnston David B R, Maccoss Malcolm, Mantlo Nathan B, Patchett Arthur A, Chakravarty Prasun K, Walsh Thomas F: Substituted imidazo-fused 5-membered ring heterocycles as angiotensin ii antagonists.. Merck & Co, January 9, 1991: EP0407102-A1 (37 worldwide citation)

There are disclosed new substituted imidazo-fused 5-membered ring heterocyclic compounds and derivatives thereof which are useful as angiotensin II antagonists. These compounds have the general formula:


14
Maccoss Malcolm, Tolman Richard L, Wagner Arthur F, Hannah John: Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives.. Merck & Co, June 11, 1986: EP0184473-A1 (36 worldwide citation)

A process for preparing 9-substituted guanine-containing acyclonucleosides comprising selective alkylation at the 9-position of the purine by utilizing a blocking group at the 6-position.


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Maccoss Malcolm, Olsen David B, Donghi Monica, Gardelli Cristina, Harper Steven, Meppen Malte, Narjes Frank, Pacini Barbara: Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection. Merck & Co, Istituto Di Ricerche Di Biologia Molecolare P Angeletti, Maccoss Malcolm, Olsen David B, Donghi Monica, Gardelli Cristina, Harper Steven, Meppen Malte, Narjes Frank, Pacini Barbara, MERCK 126 East Lincoln Avenue Rahway New Jersey 07065 0907, August 23, 2007: WO/2007/095269 (35 worldwide citation)

The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RN ...


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Chapman Kevin T, Maccoss Malcolm, Mumford Richard A, Thornberry Nancy A, Weidner Jeffrey R: Novel chromophore containing compounds.. Merck & Co, March 24, 1993: EP0533226-A2 (27 worldwide citation)

Disclosed are novel chromophore containing compounds of Formula II and their use in determining interleukin-1 beta convertase (ICE) activity. ICE has been implicated in inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; ...


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Chapman Kevin T, Thornberry Nancy A, Maccoss Malcolm, Weidner Jeffrey R, Mumford Richard A, Hagmann William K: Novel chromophore containing compounds.. Merck & Co, February 24, 1993: EP0528487-A2 (25 worldwide citation)

Disclosed are novel chromophore containing compounds of Formula I and their use in determining interleukin-1 beta convertase (ICE) activity. ICE has been implicated in inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; ...


18
Chakravarty Prasun K, Maccoss Malcolm, Mantlo Nathan, Walsh Thomas F: Angiotensin ii antagonists incorporating a substituted benzyl element.. Merck & Co, November 11, 1992: EP0512676-A1 (20 worldwide citation)

Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists.


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Allen Eric E, Maccoss Malcolm, Chakravarty Prasun K, Patchett Arthur A, Greenlee William J, Walsh Thomas F: Substituted pyrazolopyrimidines and imidazopyridazines as angiotensin ii antagonists.. Merck & Co, June 17, 1992: EP0490587-A1 (17 worldwide citation)

Novel substituted pyrazolopyrimidines and imidazopyridazines of formula (I), wherein A and B are N or C, butonly one of A or B is N angiotensin II antagonists, are disclosed. o