1
James Doherty
Dorn Conrad P, Finke Paul E, Maccoss Malcolm, Doherty James B, Shah Shrenik K, Hagmann William K: New substituted azetidinones as anti-inflammatory and antidegenerative agents.. Merck & Co, April 22, 1992: EP0481671-A1 (40 worldwide citation)

New substituted azetidinones of the general formula (A') which have been found to be potent elastase inhibitors and thereby useful anti-inflammatory and antidegenerative agents are described. e


2
Dorn Conrad P, Hale Jeffrey J, Maccoss Malcolm, Mills Sander G, Ladduwahetty Tamara, Shah Shrenik K: Morpholine and thiomorpholine tachykinin receptor antagonists.. Merck & Co, January 5, 1994: EP0577394-A1 (78 worldwide citation)

Substituted heterocycles of the general structural formula: are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, and asthma and calcium channel blockers useful in the treatment of cardiovascular conditions such as angina, hypertension or ischemia.


3
Chapman Kevin T, Thornberry Nancy A, Bull Herb G, Weidner Jeffrey R, Maccoss Malcolm, Mjalli Adnan M: Peptidyl derivatives as inhibitors of interleukin-1b converting enzyme.. Merck & Co, December 23, 1992: EP0519748-A2 (77 worldwide citation)

Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1 beta converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes ...


4
Bhat Balkrishen, Carroll Steven S, Eldrup Anne B, Maccoss Malcolm, Olsen David B, Prakash Thazha P: Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Bhat Balkrishen, Carroll Steven S, Eldrup Anne B, Maccoss Malcolm, Olsen David B, Prakash Thazha P, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, January 22, 2004: WO/2004/007512 (73 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


5
Olsen David B, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B: Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Olsen David B, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, January 8, 2004: WO/2004/003138 (70 worldwide citation)

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are partic ...


6
Maccoss Malcolm, Olsen David B, Leone Joseph, Durette Philippe L: Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of rna-dependent rna viral infection. Merck & Co, Maccoss Malcolm, Olsen David B, Leone Joseph, Durette Philippe L, MERCK 126 East Lincoln Avenue Philippe L Durette Rahway NJ 07065 0907, June 22, 2006: WO/2006/065335 (54 worldwide citation)

The present invention provides fluorinated pyrrolo[2,3,d]pyrimidine nucleoside compounds which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are p ...


7
Maccoss Malcolm, Olsen David B: Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection. Merck & Co, Maccoss Malcolm, Olsen David B, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, February 2, 2006: WO/2006/012078 (53 worldwide citation)

The present invention provides nucleoside aryl phosphoramidates which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They ar ...


8
Butora Gabor, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B: C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase. Merck & Co, Isis Pharmaceuticals, Butora Gabor, Maccoss Malcolm, Bhat Balkrishen, Eldrup Anne B, MERCK 126 East Lincoln Avenue Rahway NJ 07065 0907, December 29, 2005: WO/2005/123087 (52 worldwide citation)

The present invention provides C-purine nucleoside analogs and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are ...


9
Chang Linda L, Ashton Wallace T, Maccoss Malcolm, Chakravarty Prasun K, Greenlee William J, Patchett Arthur A, Walsh Thomas F: Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin ii antagonists.. Merck & Co, February 13, 1991: EP0412594-A2 (44 worldwide citation)

There are disclosed new substituted triazolinone, triazolinethione, and triazolinimine compounds which are useful as angiotensin II antagonists. These compounds have the general formula: t


10
Chapman Kevin T, Maccoss Malcolm: Peptidyl derivatives as inhibitors of interleukin-1b converting enzyme.. Merck & Co, June 23, 1993: EP0547699-A1 (40 worldwide citation)

Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1 beta converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes ...



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