1
Abraham P Lee, Joseph P Fitch, Daniel L Schumann, Luiz Da Silva, William J Benett, Peter A Krulevitch: Microfabricated therapeutic actuators and release mechanisms therefor. The Regents of the University of California, L E Carnahan, Alan H Thompson, May 9, 2000: US06059815 (202 worldwide citation)

Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. ...


2
Steven R Visuri, Heather L Campbell, Luiz Da Silva: Optically generated ultrasound for enhanced drug delivery. The Regents of the University of California, John P Wooldrige, Alan H Thompson, November 19, 2002: US06484052 (138 worldwide citation)

High frequency acoustic waves, analogous to ultrasound, can enhance the delivery of therapeutic compounds into cells. The compounds delivered may be chemotherapeutic drugs, antibiotics, photodynamic drugs or gene therapies. The therapeutic compounds are administered systemically, or preferably local ...


3
Peter Celliers, Luiz Da Silva, Michael Glinsky, Richard London, Duncan Maitland, Dennis Matthews, Pat Fitch: Opto-acoustic thrombolysis. The Regents of the University of California, February 8, 2000: US06022309 (126 worldwide citation)

This invention is a catheter-based device for generating an ultrasound excitation in biological tissue. Pulsed laser light is guided through an optical fiber to provide the energy for producing the acoustic vibrations. The optical energy is deposited in a water-based absorbing fluid, e.g. saline, th ...


4
Joseph P Fitch, Karla Hagans, Robert Clough, Dennis L Matthews, Abraham P Lee, Peter A Krulevitch, William J Benett, Luiz Da Silva, Peter M Celliers: Microminiaturized minimally invasive intravascular micro-mechanical systems powered and controlled via fiber-optic cable. The Regents of the University of California, Henry P Sartorio, Richard B Main, March 3, 1998: US05722989 (95 worldwide citation)

A micro-mechanical system for medical procedures is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a near end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed with ...


5
Duncan J Maitland, Abraham P Lee, Daniel L Schumann, Luiz Da Silva: Shape memory polymer (SMP) gripper with a release sensing system. The Regents of the University of California, L E Carnahan, Alan H Thompson, August 15, 2000: US06102917 (68 worldwide citation)

A system for releasing a target material, such as an embolic coil from an SMP located at the end of a catheter utilizing an optical arrangement for releasing the material. The system includes a laser, laser driver, display panel, photodetector, fiber optics coupler, fiber optics and connectors, a ca ...


6
William Benett, Peter Celliers, Luiz Da Silva, Michael Glinsky, Richard London, Duncan Maitland, Dennis Matthews, Peter Krulevich, Abraham Lee: Opto-acoustic transducer for medical applications. The Regents of the University of California, John P Wooldridge, August 31, 1999: US05944687 (58 worldwide citation)

This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through th ...


7
William Benett, Peter Celliers, Luiz Da Silva, Michael Glinsky, Richard London, Duncan Maitland, Dennis Matthews, Peter Krulevich, Abraham Lee: Opto-acoustic transducer for medical applications. The Regents of the University of California, John P Wooldridge, Alan H Thompson, April 30, 2002: US06379325 (47 worldwide citation)

This invention is an optically activated transducer for generating acoustic vibrations in a biological medium. The transducer is located at the end of a fiber optic which may be located within a catheter. Energy for operating the transducer is provided optically by laser light transmitted through th ...


8
Matthew J Everett, Billy W Colston, Dale L James, Steve Brown, Luiz Da Silva: Optical fiber head for providing lateral viewing. The Regents of the University of California, James M Skorich, Alan H Thompson, October 15, 2002: US06466713 (40 worldwide citation)

The head of an optical fiber comprising the sensing probe of an optical heterodyne sensing device includes a planar surface that intersects the perpendicular to axial centerline of the fiber at a polishing angle &thgr;. The planar surface is coated with a reflective material so that light traveling ...


9
Luiz Da Silva, Donald Cohen, Marc Lieberman: Automated cryogenic skin treatment. Vandolay, Fish & Associates PC, June 21, 2011: US07963959 (11 worldwide citation)

An apparatus and methods for treating lesions on skin are presented. The apparatus collects information about a lesion and can automatically determine a course of treatment for the lesion. The device can include a controller that positions the nozzle proximate to a surface region of the lesion and a ...


10
Johnny Leonardo Carvalho, Kl├ęber Luiz da Silva: Regulation valve. Coprecitec S L, Tim L Kitchen, Peter B Scull, Hamilton DeSanctis & Cha, October 9, 2012: US08281780 (9 worldwide citation)

A regulation valve having a valve body with a gas inlet. Housed within the valve body is a rotary regulatory body having a first inlet orifice corresponding to a first minimum flow of a first type of gas and a second inlet orifice corresponding to a second minimum flow of a second type of gas. The f ...