1
Luca Dobetti: Fast disintegrating tablets. Eurand International S p A, Thompson Hine, July 22, 2003: US06596311 (40 worldwide citation)

This invention provides a formulation for preparing a fast disintegrating tablet comprising a drug in multiparticulate form, one or more water insoluble inorganic excipients, one or more disintegrants, and optionally one or more substantially water soluble excipients, the amounts of said ingredients ...


2
Fabio Carli, Luca Dobetti: Transdermal therapeutic compositions. Vectorpharma International S p A, Birch Stewart Kolasch & Birch, December 10, 1996: US05582836 (8 worldwide citation)

There are described transdermal therapeutic compositions showing an improved shelf stability of the chemical-physical structure of the medicament and particularly useful for its cutaneous administration, said compositions consisting of a supporting rigid sheet, a polymetic matrix and a protective re ...


3
Fabio Carli, Daniela Lombardi, Pierandrea Esposito, Luca Dobetti, Luigi Boltri: Pharmaceutical compositions including a drug, a cross-linked polymeric substance, an oil, and a surface active agent. Vectorpharma International S p A, August 22, 2000: US06107276 (2 worldwide citation)

The pharmaceutical compositions including a slightly soluble drug incorporated in a water-swellable, but water-insoluble cross-linked polymer, a surface active agent, and an oil show much improved dissolution and, consequently, bioavailability in respect of the drug as is or used with a polymeric ca ...


4
Luca Dobetti, Leonardo Rabaglia, Massimo Bresciani: Drug activation process and vibrational mill therefor. Eurand Pharmaceuticals, Christensen O Connor Johnson Kindness PLLC, September 14, 2010: US07793871

The invention comprises a process for activating drugs by means of high-energy co-grinding of the drug with a pharmaceutical carrier, characterized by the use of a vibrational mill equipped with means that regulate the vibration frequency. The process, performed by modifying the frequency of vibrati ...


5
Luca Dobetti, Massimo Bresciani: Process for activation of drugs in a vibrational mill. Eurand Pharmaceuticals, Christensen O Connor Johnson Kindness PLLC, May 31, 2011: US07951399

A process is described for the activation (increase in solubility and bioavailability) of drugs. The process, carried out in a vibrational mill, is characterised by the use of given proportions between the physical mixture made up of drug and pharmaceutical carrier and the empty volume among the gri ...


6
Luigi Giovanni Mapelli, Luca Dobetti: Method for production of microcapsules. Eurand International S p A, Thompson Hine, April 6, 2004: US06716456

The invention provides a process for microencapsulating a pharmaceutical substrate comprising the steps of: a) adding insoluble or sparingly soluble particles of the substrate to be microencapsulated to a stable buffer solution having a high ionic strength; b) dissolving a membrane-forming ionic pol ...


7
Luca Dobetti, Massimo Bresciani: Process for activation of drugs in a vibrational mill. Mark P Levy, Thompson Hine, September 2, 2004: US20040170682-A1

A process is described for the activation (increase in solubility and bioavailability) of drugs. The process, carried out in a vibrational mill, is characterised by the use of given proportions between the physical mixture made up of drug and pharmaceutical carrier and the empty volume among the gri ...


8
Massimo Bresciani, Lorenzo Magarotto, Luca Dobetti: Process of thermodynamical activation of water-insoluble drugs loaded into cross-linked polymers. Thomas Hine & Flory, October 28, 2004: US20040213840-A1

The present invention refers to a process to prepare a highly activated composite of one or more water-insoluble drugs, said process comprising the steps of: (a) subjecting said water-insoluble drug and a cross-linked polymer to co-grinding; (b) exposing the ground product of step a. to contact with ...


9
Luca Dobetti, Leonardo Rabaglia, Massimo Bresciani: Drug activation process and vibrational mill therefor. Mark P Levy, Thompson Hine, August 26, 2004: US20040166155-A1

The invention comprises a process for activating drugs by means of high-energy co-grinding of the drug with a pharmaceutical carrier, characterised by the use of a vibrational mill equipped with means that regulate the vibration frequency. The process, performed by modifying the frequency of vibrati ...


10
Luca Dobetti, Leonardo Rabaglia, Massimo Bresciani: Drug activation process and vibrational mill therefor. Eurand Pharmaceuticals, Christensen O Connor Johnson Kindness Pllc, October 16, 2008: US20080251615-A1

The invention comprises a process for activating drugs by means of high-energy co-grinding of the drug with a pharmaceutical carrier, characterised by the use of a vibrational mill equipped with means that regulate the vibration frequency. The process, performed by modifying the frequency of vibrati ...