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Stéphane De Lombaert
Taeyoung Yoon, Ping Ge, Stéphane De Lombaert, Raymond F Horvath, Dario Doller, Kevin J Hodgetts, Lu Yan Zhang, Bernd Kaiser, Xuechun Zhang, Yasuchika Yamaguchi, Cunyu Zhang, Jim Darrow: 5-substituted-2-arylpyrazines. Neurogen Corporation, Peter F Corless, Dwight D Kim, Edwards Angell Palmer & Dodge, February 20, 2007: US07179807 (2 worldwide citation)

Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds can act as selective modulators or CRF receptors. Compounds of the invention are provided by the following formula: The 5-substituted-2-arylpyrazine compounds provided herein are useful in the treatment of a number of CNS and ...


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Biwersi Cathlin Marie, Warmus Joseph Scott, Zhang Lu Yan, Barrett Stephen Douglas, Kaufman Michael David, Plummer Mark Stephen, Reed Jessica Elizabeth: Mek inhibiting oxa- and thia-diazol-2-yl phenylamine derivates. Warner Lambert Company, Biwersi Cathlin Marie, Warmus Joseph Scott, Zhang Lu Yan, Barrett Stephen Douglas, Kaufman Michael David, Plummer Mark Stephen, Reed Jessica Elizabeth, LUMB J Trevor, July 8, 2004: WO/2004/056789 (28 worldwide citation)

This invention provides substituted Phenyl-(2-[1,3,4]thiadiazol-2-yl­phenyl)-amine and (2-[1,3,4]Oxadiazol-2-yl-phenyl)phenyl-amine compounds which act as inhibitors of MAPKIERK Kinase ('MEK') enzymes and pharmaceutical compositions and methods for their use in immunomodulation and in the treatment ...


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Ge Ping, Horvath Raymond F, Zhang Lu Yan, Yamaguchi Yasuchika, Kaiser Bernd, Zhang Xuechun, Zhang Suoming, Zhao He, John Stanly, Moorcroft Neil, Shutske Greg: Heteroaryl fused pyridines, pyrazines and pyrimidines as crf1 receptor ligands. Neurogen Corporation, Aventis Pharmaceuticals, ALEXANDER John B PhD, March 17, 2005: WO/2005/023806 (18 worldwide citation)

Substituted heteroaryl fused pyridine, pyrazine, and pyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, an ...


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Elliott Vicki S, Swarnakar Anita, Griffin Jennifer A, Lee Ernestine A, Sprague William W, Hafalia April J A, Lee Soo Yeun, Kable Amy E, Ison Craig H, Khare Reena, Chawla Narinder K, Marquis Joseph P, Jiang Xin, Jackson Alan A, Becha Shanya D, Emerling Brooke M, Jin Pei, Wilson Amy D, Richardson Thomas W, Yang Junming, Baughn Mariah R, Gandhi Ameena R, Nguyen Danniel B, Ramkumar Jayalaxmi, Kallick Deborah A, Kearney Liam, Lu Dyung Aina M, Gietzen Kimberly J, Tribouley Catherine M, Lal Preeti G, Blake Julie J, Lu Yan, Arvizu Chandra S: Protein modification and maintenance molecules. Incyte Corporation, Elliott Vicki S, Swarnakar Anita, Griffin Jennifer A, Lee Ernestine A, Sprague William W, Hafalia April J A, Lee Soo Yeun, Kable Amy E, Ison Craig H, Khare Reena, Chawla Narinder K, Marquis Joseph P, Jiang Xin, Jackson Alan A, Becha Shanya D, Emerling Brooke M, Jin Pei, Wilson Amy D, Richardson Thomas W, Yang Junming, Baughn Mariah R, Gandhi Ameena R, Nguyen Danniel B, Ramkumar Jayalaxmi, Kallick Deborah A, Kearney Liam, Lu Dyung Aina M, Gietzen Kimberly J, Tribouley Catherine M, Lal Preeti G, Blake Julie J, Lu Yan, Arvizu Chandra S, FOLEY Washington Harbour 3000 K Street NW Suite 500 Washington DC 20007 5143, January 29, 2004: WO/2004/009797 (11 worldwide citation)

Various embodiments of the invention provide human protein modification and maintenance molecules (PMMM) and polynucleotides which identify and encode PMMM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide meth ...


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Gao Wen, Ma Siwei, Lu Yan: A bit-rate control method and device combined with rate-distortion optimization. Inst Computing Tech Cn Academy, June 29, 2005: EP1549074-A1 (8 worldwide citation)

In the invention, a rate distortion optimization (RDO) based rate control method is comprised of following steps: first, does bit allocation for every frame in a GOP; then based on the allocated bits, a predicted quantization parameter is used to do the first rate distortion optimization mode select ...


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Lu Yan, Weidner Marcus: Coil transducer with magnetic field compensating means. Bayerische Motoren Werke, February 21, 2001: GB2353362-A (7 worldwide citation)

A transducer 10 is disclosed which is suitable for a side intrusion detection system of a vehicle. The transducer 10 is a ferro-magnetic transducer and includes a flat wound spiral form coil 12 which is arranged in use to provide self-compensation against magnetic fields which might be induced in th ...


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Eisenmann Lutz, Lu Yan: Device for adjusting head rest and method for using this kind of device. Bayerische Motoren Werke, November 7, 2000: JP2000-309242 (7 worldwide citation)

PROBLEM TO BE SOLVED: To enable the adjustment of a head rest to position optimally at a driver's head by providing two condenser plates allowing the head rest to move relatively with respect to a back rest of a vehicle seat via an electric motor. SOLUTION: A head portion 5 functions as an inductor. ...


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Ji Xiangyang, Gao Wen, Zhao Debin, Lu Yan, Ma Siwei, Qi Honggang: Bi-directional predicting method for video coding/decoding. Inst Computing Tech Cn Academy, June 21, 2006: EP1672926-A1 (6 worldwide citation)

The invention discloses a bi-directional prediction method for video coding/decoding. When bi-directional prediction coding at the coding end, firstly the given forward candidate motion vector of the current image block is obtained for every image block of the current B-frame; the backward candidate ...


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Matsubara Shigeo, Amino Hiroyuki, Aoyama Susumu, Lu Yan: Apparatus for dieless forming plate materials. Amino, Matsubara Shigeo, January 12, 2000: EP0970764-A1 (6 worldwide citation)

The invention relates to an apparatus for the dieless forming of a sheet. The apparatus comprises a pressing mechanism and a sheet holding mechanism which are moved with respect to each other in X, Y and Z-axis directions and has a fixed ceiling plate form having a plane shape matching the bottom pr ...