1
Tianbao Lu, Louis V Lafrance III, Daniel J Parks, Karen L Milkiewicz, Raul R Calvo, Maxwell D Cummings, Alexander J Kim, Bruce L Grasberger, Theodore E Carver Jr: Substituted 1,4-benzodiazepines and uses thereof. Laura Donnelly, June 27, 2006: US07067512 (3 worldwide citation)

The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: X and Y are independently —C(O)—, —CH ...


2
Tianbao Lu, Karen L Milkiewicz, Pierre Raboisson, Maxwell David Cummings, Raul R Calvo, Daniel J Parks, Louis V Lafrance III, Juan Jose Marugan Sanchez, Joan Gushue, Kristi Leonard: Substituted 1,4-diazepines and uses thereof. Ortho McNeil Pharmaceutical, Laura Donnelly, October 3, 2006: US07115598 (2 worldwide citation)

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: R1, R2, R9, R10, Ra, Rd and M are defined ...


3
Charles William Blackledge Jr, Joelle Lorraine Burgess, Neil W Johnson, Jiri Kasparec, Steven David Knight, Louis V LaFrance III, Juan I Luengo, William Henry Miller, Kenneth Allen Newlander, Stuart Paul Romeril, Mark Schulz, Dai Shi Su, Xinrong Tian: Enhancer of zeste homolog 2 inhibitors. GlaxoSmithKline Intellectual Property, Duke M Fitch, Kathryn A Lutomski, Edward R Gimmi, November 29, 2016: US09505745

This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.