1
Tianbo Lu, Louis V LaFrance, Thomas P Markotan, Juan J Marugan Sanchez, Victor J Marder, David C U Prichard, Beth M Anaclerio, Zihong Guo, Wenzi Pan, Kristi A Leonard, Bruce E Tomczuk: Substituted indoles and their use as integrin antagonists. Dimensional Pharmaceuticals, Woodcock Washburn, February 15, 2005: US06855722 (5 worldwide citation)

The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological condit ...


2
Tianbao Lu, Louis V Lafrance III, Daniel J Parks, Karen L Milkiewicz, Raul R Calvo, Maxwell D Cummings, Alexander J Kim, Bruce L Grasberger, Theodore E Carver Jr: Substituted 1,4-benzodiazepines and uses thereof. Laura Donnelly, June 27, 2006: US07067512 (3 worldwide citation)

The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: X and Y are independently —C(O)—, —CH ...


3
Tianbo Lu, Bruce E Tomczuk, Louis V LaFrance, Thomas P Markotan, Juan J Marugan Sanchez, Victor J Marder, David C U Prichard, Beth M Anaclerio, Zihong Guo, Wenzi Pan, Kristi A Leonard: Substituted indoles and their use as integrin antagonists. 3 Dimensional Pharmaceutical, July 10, 2007: US07241789 (2 worldwide citation)

The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological condit ...


4
Tianbao Lu, Karen L Milkiewicz, Pierre Raboisson, Maxwell David Cummings, Raul R Calvo, Daniel J Parks, Louis V Lafrance III, Juan Jose Marugan Sanchez, Joan Gushue, Kristi Leonard: Substituted 1,4-diazepines and uses thereof. Ortho McNeil Pharmaceutical, Laura Donnelly, October 3, 2006: US07115598 (2 worldwide citation)

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: R1, R2, R9, R10, Ra, Rd and M are defined ...


5
Charles William Blackledge Jr, Joelle Lorraine Burgess, Neil W Johnson, Jiri Kasparec, Steven David Knight, Louis V LaFrance III, Juan I Luengo, William Henry Miller, Kenneth Allen Newlander, Stuart Paul Romeril, Mark Schulz, Dai Shi Su, Xinrong Tian: Enhancer of zeste homolog 2 inhibitors. GlaxoSmithKline Intellectual Property, Duke M Fitch, Kathryn A Lutomski, Edward R Gimmi, November 29, 2016: US09505745

This invention relates to novel compounds according to Formula (I) which are inhibitors of Enhancer of Zeste Homolog 2 (EZH2), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.


6
Tianbao Lu, Karen L Milkiewicz, Pierre Raboisson, Maxwell David Cummings, Raul R Calvo, Daniel J Parks, Louis V Lafrance, Juan Jose Marugan Sanchez, Joan Gushue, Kristi Leonard: Substituted 1,4-diazepines and uses thereof. Philip S Johnson, Johnson & Johnson, November 4, 2004: US20040220179-A1

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: 1 or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: R1, R2, R9, R10, Ra, Rd and M are define ...


7
Tianbao Lu, Karen L Milkiewicz, Pierre Raboisson, Maxwell David Cummings, Raul R Calvo, Daniel J Parks, Louis V LaFrance, Juan Jose Marugan Sanchez, Joan Gushue, Kristi Leonard: Substituted 1,4-diazepines and uses thereof. Philip S Johnson, Johnson & Johnson, October 19, 2006: US20060235007-A1

The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: R1, R2, R9, R10, Ra, Rd and M are defined h ...


8
Tianbao Lu, Louis V Lafrance, Daniel J Parks, Karen L Milkiewicz, Raul R Calvo, Maxwell D Cummings, Alexander J Kim, Bruce L Grasberger, Theodore E Carver: Substituted 1,4-benzodiazepines and uses thereof. Sterne Kessler Goldstein & Fox Pllc, June 12, 2003: US20030109518-A1

The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: 1 or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: X and Y are independently —C(O)—, — ...


9
Tianbao Lu, Louis V LaFrance, Thomas P Markotan, Juan Jose Marugan, Victor J Marder, David C U Prichard, Beth M Anaclerio, Zihong Guo, Wenxi Pan, Kristi A Leonard: Substituted indoles and their use as integrin antagonists. 3 Dimensional Pharmaceuticals, Sterne Kessler Goldstein & Fox Pllc, November 14, 2002: US20020169200-A1

The present invention relates to novel substituted indole compounds that are antagonists of alpha V (v) integrins, for example v3 and v5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions ...


10
Tianbao Lu, Louis V LaFrance, Bruce E Tomczuk, Thomas P Markotan, Juan J Marugan Sanchez, Victor J Marder, David C U Prichard, Beth M Anaclerio, Zihong Guo, Wenzi Pan, Kristi A Leonard: Substituted indoles and their use as integrin antagonists. 3 Dimensional Pharmaceuticals, Philip S Johnson, Johnson & Johnson, September 22, 2005: US20050209225-A1

The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example αvβ3 and αvβ5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological condit ...