1
Louis C Sehl, Olof Mikael Trollsas, Donald G Wallace, David Toman, Frank A DeLustro, Jacqueline A Schroeder, George H Chu: Methods for tissue repair using adhesive materials. Cohesion Technologies, Dianne E Reed, Mark L Warzel, Reed Intellectual Property Law Group, December 21, 2004: US06833408 (158 worldwide citation)

A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction betwe ...


2
Louis C Sehl, Olof Mikael Trollsas, Donald G Wallace, David Toman, Frank A DeLustro, Jacqueline A Schroeder, George H Chu: Compositions and systems for forming crosslinked biomaterials and methods of preparation of use. AngioDevice International, Seed IP Law Group PLLC, February 8, 2011: US07883693 (26 worldwide citation)

Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked materials that may be used as adhesive compositions. The compositions comprise collagen and a plurality of crosslinkable components having reactive functional groups thereon, w ...


3
George Y Daniloff, Louis C Sehl, Olof Mikael Trollsas, Jacqueline Schroeder, David M Gravett, Philip M Toleikis: Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use. AngioDevice International, Seed IP Law Group PLLC, November 29, 2011: US08067031 (22 worldwide citation)

Crosslinkable compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the c ...


4
Pasit Phiasivongsa, Louis C Sehl, William Dean Fuller, Guy J Laidig: Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides. Onyx Therapeutics, Fish & Richardson P C, February 5, 2013: US08367617 (18 worldwide citation)

The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the des ...


5
George Y Daniloff, Louis C Sehl, Olof Mikael Trollsas, Jacqueline A Schroeder, David M Gravett, Philip M Toleikis: Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use. AngioDevice International, Seed IP Law Group PLLC, June 11, 2013: US08460708 (7 worldwide citation)

Kits comprising dry power compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The dry powder composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter ...


6
Pasit Phiasivongsa, Louis C Sehl: Crystalline tripeptide epoxy ketone protease inhibitors. Onyx Therapeutics, Fish & Richardson P C, December 10, 2013: US08604215 (7 worldwide citation)

The invention relates to crystalline tripeptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. In addition, the compounds provided herein are immunoproteasome inhibitors and are useful, for example, in the treatment of cancer and autoimmune disease. In ...


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George Y Daniloff, Louis C Sehl, Olof Mikael Trollsas, Jacqueline A Schroeder, David M Gravett, Philip M Toleikis: Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use. AngioDevice International, Seed IP Law Group PLLC, July 9, 2013: US08481073 (4 worldwide citation)

Methods of preventing adhesion between issues are provided that utilizes in situ crosslinked biomaterials. The biomaterial contains at least the crosslinked product of two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable in ...


9
Louis C Sehl, Olof Mikael Trollsas, Donald G Wallace, David Toman, Frank A DeLustro, Jacqueline A Schroeder, George H Chu: Adhesive tissue repair patch. Angiotech Pharmaceuticals, Seed IP Law Group PLLC, February 19, 2013: US08377466 (2 worldwide citation)

A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction betwe ...


10
Louis C Sehl, Olof Mikael Trollsas, Donald G Wallace, David Toman, Frank A DeLustro, Jacqueline A Schroeder, George H Chu: Adhesive tissue repair patch and collagen sheets. Angiodevice International, Seed IP Law Group PLLC, December 31, 2013: US08617584

The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that ...