1
G Richard Cathcart, Thomas Brennan Marquez, John A Bridgham, George S Golda, Harry A Guiremand, Marianne Hane, Louis B Hoff, Eric Lachenmeier, Melvyn N Kronick, Douglas H Keith, Paul E Mayrand, Michael L Metzker, William J Mordan, Lincoln J McBride, John Shigeura, Chen Hanson Ting, Norman M Whiteley: Automated molecular biology laboratory. Perkin Elmer Applied Biosystems Division, Donald R Boys, Joseph H Smith, August 22, 1995: US05443791 (318 worldwide citation)

A liquid-handling instrument has a worksurface with registration for modular stations to support containers of liquid, pipette apparatus with a pipette tip coupled to a sensing circuit, a robotic translation system for moving the pipette tip, and a control system with an iconic user interface for pr ...


2
Louis B Hoff, Mark F Oldham: Shaped illumination geometry and intensity using a diffractive optical element. PE Corporation, Finnegan Henderson Farabow Garrett & Dunner L, June 1, 2004: US06744502 (24 worldwide citation)

A method and apparatus to illuminate a target. The apparatus can comprise a first lens configured to receive light from the light source, a diffractive optical element configured to receive the light from the first lens and to regulate the light into regulated light, and second lens configured to re ...


3
Louis B Hoff, Mark F Oldham: Shaped illumination geometry and intensity using a diffractive optical element. Applera Corporation Applied Biosystems Group, Finnegan Henderson Farabow Garrett & Dunner, February 28, 2006: US07006215 (23 worldwide citation)

A method and apparatus to illuminate a target. The apparatus can comprise a first lens configured to receive light from the light source, a diffractive optical element configured to receive the light from the first lens and to regulate the light into regulated light, and second lens configured to re ...


4
Louis B Hoff, Eric W Lachenmeier, Yefim M Raysberg, Eric S Nordman: Real-time scanning fluorescence electrophoresis apparatus for the analysis of polynucleotide fragments. The Perkin Elmer Corporation, Paul D Grossman, August 6, 1996: US05543026 (23 worldwide citation)

This invention relates to an improved real-time scanning fluorescence electrophoresis apparatus for the electrophoretic analysis of fluorescently-labeled polynucleotide fragments. The apparatus is characterized by having an electrophoresis chamber containing an electrophoretic separation medium capa ...


5
John Shigeura, John A Bridgham, Louis B Hoff, P Eric Mayrand: Horizontal polyacrylamide gel electrophoresis. Applied Biosystems, Donald R Boys, Joseph H Smith, August 16, 1994: US05338426 (20 worldwide citation)

An electrophoresis apparatus has a gel film cast between two plates and buffer reservoirs at each end of the film with electrodes connectable to an external power supply for providing electromotive force for driving electrophoresis. The reservoirs are configured to wet the ends of the gel film and s ...


6
Shaheer H Khan, Roger A O Neill, Louis B Hoff: Method and apparatus for automated carbohydrate mapping and sequencing. The Perkin Elmer Corporation, Paul D Grossman, August 25, 1998: US05798032 (8 worldwide citation)

Methods and apparatus are disclosed for improved mapping and sequencing of carbohydrate polymers. In one aspect, the improvement includes a means for coupling two capillary electrophoresis (CE) tubes in such a way so as to (i) efficiently transfer a selected sample component from a first CE capillar ...


7
Scott R Warren, Louis B Hoff, Mark F Oldham: Multiaxis focusing mechanism for microarray analysis. Life Technologies Corporation, January 18, 2011: US07871810

Systems and methods for positioning a multi-featured biological array relative to a signal acquisition device. Detection of the array's positional deviation may be achieved by a calibration beam reflected from the array surface and detected by a position sensitive detector (PSD). The PSD-measured po ...


8
Louis B Hoff, Mark F Oldham: Shaped illumination geometry and intensity using a diffractive optical element. Finnegan Henderson Farabow Garrett & Dunner, April 8, 2004: US20040066510-A1

A method and apparatus to illuminate a target. The apparatus can comprise a first lens configured to receive light from the light source, a diffractive optical element configured to receive the light from the first lens and to regulate the light into regulated light, and second lens configured to re ...


9
Louis B Hoff, Mark F Oldham: Shaped illumination geometry and intensity using a diffractive optical element. Applera Corporation, Finnegan Henderson Farabow Garrett & Dunner, January 6, 2005: US20050002026-A1

A method and apparatus to illuminate a target. The apparatus can comprise a first lens configured to receive light from the light source, a diffractive optical element configured to receive the light from the first lens and to regulate the light into regulated light, and second lens configured to re ...


10
Scott R Warren, Louis B Hoff, Mark F Oldham: Multiaxis focusing mechanism for microarray analysis. Knobbe Martens Olson & Bear, May 4, 2006: US20060094027-A1

Systems and methods for positioning a multi-featured biological array relative to a signal acquisition device. Detection of the array's positional deviation may be achieved by a calibration beam reflected from the array surface and detected by a position sensitive detector (PSD). The PSD-measured po ...